Examining adherence to immunosuppressive medications in new liver transplant patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how well newly transplanted liver patients adhere to immunosuppressive medications, specifically comparing a once-daily formulation (Advagraf®) to a twice-daily formulation (Prograf). It is a prospective, multi-center, open-labeled, randomized clinical trial that will enroll participants in Taiwan. Patients will be randomized on postoperative day 15 to assess their adherence and convenience with the medication regimen. The study aims to improve patient outcomes by optimizing medication adherence in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient has been fully informed and has signed an IRB approved informed consent form within 7 days (Day 7-13) prior to POD 15 and is willing and able to follow study procedure
* Patient is a primary liver transplant recipient
* Patient is 20 to 70 years of age
* Patient should be clearly conscious, fully understand and able to answer questionnaire

Exclusion Criteria:

* Patient has previously received or is receiving an organ transplant other than a liver.
* Patient currently requires dialysis
* Recipient or donor is known to be seropositive for human immunodeficiency virus (HIV)
* Patient has received a liver transplant from a non-heart beating donor
* Patient who is HCV negative has received an HCV positive (HCV RNA by PCR or HCV antibody) donor liver
* Patient who is HbsAg negative has received an HbsAg positive (HBV DNA by PCR or HBV antibody) donor liver
* Patient has received a liver transplant from a decrease donor \> 70 years of age
* Patient has a current malignancy or a history of malignancy (within the past 5 years), except hepatocellular carcinoma within UCSF Criteria and basal or non-metastatic squamous cell carcinoma of skin that has been treated successfully.
* Patient is hemodynamically unstable on POD 15

Where it's running

• Chang Gung Memorial Hospital
  Taoyuan, Taiwan Recruiting

Study contacts

• Principal investigator: Wei-Chen Lee — Cgmh
• Study coordinator: Wei-Chen Lee
• Email: weichen@cgmh.org.tw
• Phone: 09753-68195

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.