Evaluation of the Resilience Clinic for children and caregivers facing adversity

The Resilience Clinic: Program Evaluation and Quality Improvement

Not applicable Interventional University of California, San Francisco · NCT05690256

This study is testing a new program called the Resilience Clinic to see if it helps young children and their caregivers who have faced tough times feel better and develop healthier habits.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment200 (estimated)
Ages2 Years to 5 Years
SexAll
SponsorUniversity of California, San Francisco Academic / other
Drugs / interventionsradiation
Locations4 sites (Oakland, California and 3 other locations)
Trial IDNCT05690256 on ClinicalTrials.gov

What this trial studies

The Resilience Clinic is a psychoeducational intervention designed for young children and their caregivers who have experienced early life adversity. This program aims to prevent the harmful effects of toxic stress by promoting resilience and improving health, behavior, and development in children aged 0-5 years. The study evaluates the efficacy and operational feasibility of the Resilience Clinic by comparing caregiver-child dyads receiving the intervention to a control group from a concurrent clinical trial. The intervention includes both clinic-based and community-based approaches to support families in managing stress and adversity.

Who should consider this trial

Good fit: Ideal candidates include primary caregivers aged 18 and older of children aged 2 to 5 years who have experienced significant adversity.

Not a fit: Patients with active suicidality, other psychiatric issues, or children with significant medical co-morbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve the health and developmental outcomes of children exposed to early life adversity while also reducing caregiver stress.

How similar studies have performed: Other studies have shown promise in similar interventions aimed at mitigating the effects of early life adversity, indicating that this approach is both relevant and potentially effective.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Caregiver: 18 years old and older, primary caregiver, English or Spanish speaking
* Child: 2 to 5 years, PEARLS score \> 1 or verbal disclosure of PEARLS adversity to primary care clinician/staff

Exclusion Criteria:

* Caregiver: active suicidality, other psychiatric issues
* Child: significant medical co-morbidities (i.e. disease requiring immunomodulators, chemo or radiation therapy, or hormonal therapy)

Where this trial is running

Oakland, California and 3 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Early Life AdversityCaregiver Stresstoxic stressadverse childhood experiences
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.