Evaluation of a mobile app for managing opioid use disorder

Evaluation of KIOS in a 12-week Randomized Controlled Trial

Not applicable Interventional The University of Texas Health Science Center at San Antonio · NCT06212557

This study tests whether a mobile app can help people recovering from opioid use disorder manage their condition better than standard treatment methods.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment210 (estimated)
Ages18 Years and up
SexAll
SponsorThe University of Texas Health Science Center at San Antonio Academic / other
Locations1 site (San Antonio, Texas)
Trial IDNCT06212557 on ClinicalTrials.gov

What this trial studies

This study evaluates the KIOS mobile app, designed to assist individuals recovering from opioid use disorder (OUD) in self-managing their condition. It compares the app's effectiveness against standard treatment methods, providing personalized, evidence-based behavioral interventions based on real-time patient data. Participants will have 24/7 access to the app, which aims to enhance their engagement and response to traditional clinic-based counseling. The study is conducted with outpatients who are currently enrolled in medication-assisted treatment for OUD in Texas.

Who should consider this trial

Good fit: Ideal candidates are outpatients aged 18 and older who are currently participating in medication-assisted treatment for opioid use disorder and can access the app via a smartphone or tablet.

Not a fit: Patients who are incarcerated or have psychiatric or medical disorders that hinder their ability to use the app may not benefit from this study.

Why it matters

Potential benefit: If successful, this app could significantly improve self-management and recovery outcomes for patients with opioid use disorder.

How similar studies have performed: Other studies have shown promise in using digital health interventions for substance use disorders, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Male or female outpatients 18 years of age or older
2. Patients must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
3. DSM-5 (Diagnostic and Statistical Manual of Mental Disorders fifth edition) criteria for opioid use disorder
4. Ability to access KIOS via smartphone or tablet
5. Recently (less than 6 months) enrolled in and currently participating in MOUD at a clinic in Texas

Exclusion Criteria:

1. Unwilling or unable to comply with study requirements
2. Psychiatric or medical disorder interfering with ability to use the app
3. Incarceration

Where this trial is running

San Antonio, Texas

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Opioid Use DisorderDigital health therapeuticBehavioral intervention strategiesClinic-based counseling
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.