Evaluation and treatment of neurosurgical disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational protocol aims to evaluate participants with neurosurgical disorders receiving care at the Surgical Neurology Branch. Participants aged 4 years and older will undergo standard clinical evaluations and treatments, which may include laboratory and radiological studies. Clinical data and samples collected during these evaluations will be utilized for research purposes, including potential genetic testing for those with suspected hereditary conditions. The study focuses on a range of neurologic disorders, including brain tumors, epilepsy, and Parkinson's disease.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

  1. Participants must be age 4 and older.
  2. Participants must seek care from, or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epilepsy, Parkinson s disease, movement disorders, Chiari syndrome, central nervous system malformations, and pain disorders)
  3. For adults: able to provide informed consent or having a legally-authorized representative to provide consent, if incapacitated
  4. For minors: a parent or legal guardian who is able to provide consent.

     For immediate blood relatives of subjects having genetic testing only:
  5. Blood relative of a subject who is suspected to have a genetic mechanism underlying their neurological disorder (for genetic testing only).

EXCLUSION CRITERIA:

1\. Patients who are unable to undergo evaluation and treatment for a neurosurgical disorder

3.c. Participant Inclusion Criteria for the cohort with processing of biological samples only (for those subjects who are only having skin biopsies and/or saliva samples)

1. Participants must be age 4 and older.
2. Participants must seek care from or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epilepsy, Parkinson s disease, movement disorders, Chiari syndrome, central nervous system malformations, and pain disorders)
3. For adults: able to provide informed consent or having a legally-authorized representative to provide consent, if incapacitated
4. For minors: a parent or legal guardian who is able to provide consent.
5. Be willing to consent for collection of clinical data or biological samples or their cryopreservation

3.D. Participant Exclusion Criteria for the cohort with processing of biological samples only (for those subjects who are only having skin biopsies and/or saliva samples)

1. Patients who are unable to undergo evaluation and treatment for a neurosurgical disorder
2. At the time of enrollment, subjects without an established diagnosis of a wellcharacterized disease entity with validated treatment algorithms. In such cases, proposed resource investment, in the opinion of the investigators, would not contribute to further advancement of knowledge

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: John D Heiss, M.D. — National Institute of Neurological Disorders and Stroke (NINDS)
• Study coordinator: Surgical Neurology Branch
• Email: nindsdir-snbrecruiti@ninds.nih.gov
• Phone: (301) 496-2921

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.