Evaluating zanubrutinib treatment in patients with certain blood cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to gather and analyze real-world data on adult patients with Waldenström's Macroglobulinemia, Chronic Lymphocytic Leukemia, Marginal Zone Lymphoma, and Follicular Lymphoma who are receiving treatment with zanubrutinib. The study will assess medical resource utilization, treatment effectiveness, safety, tolerability, and patient satisfaction, along with health-related quality of life. By focusing on patients with various treatment histories and comorbidities, the study seeks to fill gaps in existing data regarding this treatment option.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Waldenström's macroglobulinemia (all treatment lines) OR
* Chronic lymphocytic leukemia (all treatment lines) OR
* Marginal zone lymphoma (≥2 treatment line and at least one anti-CD20 antibody-based previous therapy)
* Follicular lymphoma (≥3 treatment line)
* Signed and dated informed consent form
* Treatment with zanubrutinib according to current SmPC for WM, CLL and MZL
* Treatment with zanubrutinib + obinutuzumab for FL according to current SmPC
* Treatment decision before inclusion into this non-interventional study
* Age ≥18 years.

Exclusion Criteria:

* Contraindications according to SmPC for patients with WM, CLL, MZL or FL
* Participation in an interventional clinical trial during zanubrutinib treatment.

Where it's running

• Universitätsklinikum Salzburg, Klinik für Innere Medizin III
  Salzburg, Austria Recruiting
• Lübecker Onkologische Schwerpunktpraxis
  Lübeck, Schleswig-Holstein, Germany Recruiting

Study contacts

• Principal investigator: Jens Kisro, Dr. — Lübecker Onkologische Schwerpunktpraxis
• Study coordinator: Daniel Kummer, Dr.
• Email: ariadne@iomedico.com
• Phone: +49761152420

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.