Evaluating Vitamin C Levels in Patients with Chronic Rheumatism
Evaluation of Plasma Vitamin C Levels in a Population of Chronic Rheumatism in Immuno-Rheumatology
This study is testing whether low vitamin C levels are linked to ongoing pain in people with chronic rheumatism, like lupus and spondyloarthritis, who are otherwise doing well.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice, Alpes Maritimes) |
| Trial ID | NCT05345899 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate plasma vitamin C levels in patients suffering from chronic inflammatory rheumatism, specifically lupus and spondyloarthritis. It focuses on individuals who are in remission or have low disease activity but still experience unexplained pain. By assessing vitamin C levels, the study seeks to understand the potential link between vitamin C deficiency and residual pain in these patients. The methodology includes measuring plasma vitamin C levels and evaluating the quality of life of participants.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with chronic inflammatory rheumatism in remission or low activity, experiencing unexplained pain.
Not a fit: Patients who are pregnant, nursing, or unable to participate in clinical trials due to legal restrictions will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of pain in patients with chronic rheumatism through vitamin C supplementation.
How similar studies have performed: While the specific approach of evaluating vitamin C levels in this context may be novel, other studies have explored the role of vitamins in managing chronic conditions with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patient over 18 years-old, * followed for chronic inflammatory rheumatism (RIC): spondylo-arthritis (including spondylitis and psoriatic rheumatism) and lupus, * with RIC in remission or low activity definec according to the following criteria: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) criteria and Bath Ankylosing Spondylitis Fonctional Index (BASFI) questionnaire for spondylitis and psoriatic rheumatism, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) 2K score for lupus, * having given written consent after written and oral information, * member of the social security system, * basic treatment for the disease not modified for at least 6 months, without modification at baseline * persistence of painful complaints not objectively explained by his RIC. Exclusion Criteria: * pregnant or nursing patient, * patient protected by law or under guardianship or curatorship, or not able to participate in a clinical trial under L.1121-16 article of French Public Health Regulations, * patient participating in or having participated in another drug clinical trial in the month prior to inclusion.
Where this trial is running
Nice, Alpes Maritimes
- CHU de Nice — Nice, Alpes Maritimes, France (Recruiting)
Study contacts
- Study coordinator: Nathalie TIEULIE
- Email: tieulie.n@chu-nice.fr
- Phone: 04 92 03 90 19
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.