Evaluating treatment options for severe nosebleeds

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares two management strategies for severe epistaxis: endoscopic ligation and supra-selective embolization. It aims to determine which method is more cost-effective while also improving patient quality of life. The research will assess factors such as recurrence rates, hospital stay lengths, and postoperative care costs. By randomizing patients who have not responded to initial treatments, the study seeks to provide clearer guidelines for managing severe nosebleeds.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient with severe epistaxis who failed treatment with double tamponade for more than 48 hours.
* Patient over 18 years old
* Affiliated patient or beneficiary of a social security scheme.
* Patient accepting the principle of randomization
* Free, informed and written consent, signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research).

Exclusion Criteria:

* Patient with epistaxis secondary to facial and/or surgical trauma.
* Patient with epistaxis related to a malignant tumor cause
* Patient with a history of ligation or embolization
* Patient under legal protection and/or curatorship and/or guardianship.
* Impossibility of giving the person informed information and ensuring the subject's compliance due to impaired physical and/or psychological health.
* Patient participating in another research including an exclusion period still in progress
* Pregnant or breastfeeding patient

For non randomized patient

* Patient with a contraindication to general anesthesia: severe and/or decompensated cardiac/hepatic/renal insufficiency, ASA score 4
* Severe hemostasis disorders that cannot benefit from correction.
* History of transient and/or definitive stroke of the ischemic type
* Atheromatous overload

Where it's running

• University Hospital
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Guillaume DE BONNECAZE, MD — University Hospital, Toulouse
• Study coordinator: Guillaume DE BONNECAZE, MD
• Email: debonnecaze.g@chu-toulouse.fr
• Phone: 0567771641

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.