Evaluating TPST-1495 for treating colorectal and endometrial cancers before surgery

A Phase 2 Pilot Window of Opportunity Study of the EP2 and EP4 Receptors Inhibitor TPST-1495 in Patients With Endometrial Cancer or Colorectal Cancer Planning to Undergo Surgical Therapy

This study is testing if a new drug called TPST-1495 can help boost the immune response in people with colorectal and endometrial cancers before their surgery.

Quick facts

• Phase: PHASE2
• Study type: Interventional
• Enrollment: 10 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University of Oklahoma (other)
• Drugs / interventions: chemotherapy, radiation
• Locations: 1 site (Oklahoma City, Oklahoma)
• Trial ID: NCT06129604 on ClinicalTrials.gov

What this trial studies

This pilot trial investigates the safety and biological effectiveness of TPST-1495, a dual antagonist targeting specific prostaglandin E2 receptors, in patients with endometrial and colorectal cancers. Participants will receive 50mg of TPST-1495 orally once daily for seven days, with treatment stopping three days before their scheduled surgery. The study aims to assess the drug's potential to enhance the immune response against these cancers by analyzing blood samples and tumor tissues before and after treatment. A total of 20 participants will be enrolled, with 10 evaluable patients targeted for analysis.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with histologically confirmed endometrial or colorectal cancer who are candidates for surgical therapy and have not received prior chemotherapy or radiation.

Not a fit: Patients with prior chemotherapy or radiation treatment for their cancer may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could enhance the immune system's ability to fight colorectal and endometrial cancers, potentially improving surgical outcomes.

How similar studies have performed: While this approach is based on promising preclinical findings, it is a pilot study and may be considered novel in the context of its specific application to these cancers.

Eligibility criteria

Inclusion Criteria:

1. Written informed consent signed and dated by the patient prior to the performance of any study- specific procedures.
2. At least 18 years of age at the time of signature of the informed consent form (ICF)
3. Histologically confirmed endometrial cancer or colorectal cancer of any stage; either newly diagnosed or recurrent cancer, however no prior chemotherapy or radiation will be allowed.
4. Must be candidates for surgical therapy.
5. Male or female patients. Male patients with female partners of childbearing potential and female patients of childbearing potential are required to use two highly effective methods of contraception during the study treatment and for 3 months after the treatment termination visit. In addition, women of childbearing potential are required to undergo serum pregnancy testing at screening, and at the treatment termination visit.

   Male study participants should refrain from sperm donation during study treatment and up to 3 months following the last dose of TPST-1495
6. To have archival tumor tissue specimen available. Otherwise, patients should agree to have tumor biopsy to obtain sufficient tissue for histological assessment.
7. Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1.
8. Life expectancy estimated to be \> 12 weeks.
9. Adequate organ and marrow function as defined in protocol.

Exclusion Criteria:

1. Concurrent enrollment in another clinical study, unless it is an observational clinical study, a specimen-collection study, or the follow-up period of an interventional study.
2. Patients who used NSAID or COX-2 inhibitors with duration of 4 days or longer within 2 weeks prior to study treatment initiation.
3. Patients with past medical history (PMH) of allergy or hypersensitivity, GI bleed, or ulceration secondary to NSAID's or COX-2 inhibitors.
4. PMH of GI ulcer within one year of treatment initiation or history of untreated helicobacter's pylori infection. Subjects with history of treated helicobacter's pylori infection with confirmation of eradication are eligible.
5. PMH of diverticulitis or any GI bleed within 2 years of treatment initiation.
6. Heart failure is classified by New York Heart Association as Classification II, III or IV.
7. Patients with history of MI or TIA/CVA will be excluded.
8. Active autoimmune disease or inflammatory disorders including inflammatory bowel disease (e.g., ulcerative colitis or Crohn's disease) requiring systemic treatment (i.e., with use of disease modifying agents, systemic corticosteroids, or immunosuppressive drug) within 2 years prior to treatment initiation.
9. Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrythmia, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations including a history of substance abuse that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent.
10. Subjects who are receiving anticoagulant therapy or considered to be at increased risk of bleeding (i.e., bleeding disorder or coagulopathy).
11. Psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol and/or follow-up procedures outlined in the protocol.
12. Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen should be included.

Where this trial is running

Oklahoma City, Oklahoma

• OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma, United States (RECRUITING)

Study contacts

• Principal investigator: Susanna Ulahannan, MD — OU Health Stephenson Cancer Center
• Study coordinator: Lead Nurse

Conditions: Colorectal Carcinoma, Endometrial Carcinoma