Evaluating thyroid nodules using advanced ultrasound techniques
Multimodality US Based on Angio Planewave Ultrasensitive Imaging and Shear Wave Elastography to Guide the Fine-Needle Aspiration Management of Thyroid Lesions: Focus on the Innovative Microvascular Classification
Fifth Affiliated Hospital, Sun Yat-Sen University · NCT06530771
This study is testing a new ultrasound method to see if it can help doctors tell the difference between harmless and cancerous thyroid nodules in patients before surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 720 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Fifth Affiliated Hospital, Sun Yat-Sen University (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Zhuhai, Guangdong) |
| Trial ID | NCT06530771 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to assess the effectiveness of a multimodal ultrasound approach that combines Angio Planewave Ultrasensitive Imaging, Shear Wave Elastography, and grayscale ultrasound to differentiate between benign and malignant thyroid nodules. Participants will undergo these ultrasound examinations within a week prior to surgery, where the results will be compared to postoperative pathological diagnoses. The study seeks to determine if an innovative ultra-microvascular classification system can improve the accuracy of thyroid nodule evaluations and guide fine-needle aspiration management.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years with one or more thyroid nodules detectable by ultrasound who are scheduled for surgical evaluation.
Not a fit: Patients with nodules that have large calcifications, a history of previous neck surgery or cancer, or those who have received thyroid medications or radiation treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses of thyroid nodules, reducing unnecessary surgeries and improving patient outcomes.
How similar studies have performed: While this approach is innovative, similar studies using advanced ultrasound techniques have shown promise in improving diagnostic accuracy for thyroid nodules.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. age more than 18 years; 2. Voluntarily signed informed consent; 3. Have 1 or more thyroid nodules detectable by ultrasound; 4. participant underwent surgical procedure to confirm the pathologic results Exclusion Criteria: 1. Nodules are accompanied by large calcifications followed by acoustic shadows 2. History of previous neck surgery or cancer, thyroid medications, radiation or surgical treatment; 3. Poor quality of retained images or non-standard operations (such as intermittent scanning and improper probe compression), and incomplete pathological results.
Where this trial is running
Zhuhai, Guangdong
- The Fifth Affiliated Hospital Sun Yat-Sen University — Zhuhai, Guangdong, China (RECRUITING)
Study contacts
- Study coordinator: Xin Wen
- Email: wenxin7@mail.sysu.edu.cn
- Phone: 15913232456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multimoda Lultasound, Thyroid Cancer, Microvascular Classification