Evaluating thrombosis related to central venous catheters using advanced CT imaging
Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central Venous Catheters (PHOTO CAT)
Region Skane · NCT06417541
This study is testing a new type of CT scan to see how often blood clots happen in patients with central venous catheters, both in those who have passed away and those still living.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Region Skane (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Lund, Skåne County) |
| Trial ID | NCT06417541 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the prevalence of subclinical thromboses associated with central venous catheters (CVCs) through the use of a novel photon-counting computed tomography (CT) scan. It consists of two sub-studies: one involving deceased patients with CVCs undergoing autopsy, and another involving living patients with CVCs referred for CT scans without contrast. The results from the photon-counting CT will be compared to findings from clinical autopsies to evaluate its diagnostic performance. The study seeks to enhance understanding of CVC-related thrombosis and improve imaging techniques.
Who should consider this trial
Good fit: Ideal candidates include deceased patients with an indwelling central venous catheter referred for autopsy and living patients with an indwelling central venous catheter referred for CT scans without contrast.
Not a fit: Patients with a glomerular filtration rate (GFR) less than 15 mL/min/1.73 m² may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better detection and management of thrombosis in patients with central venous catheters, potentially improving patient outcomes.
How similar studies have performed: While studies have reported incidences of thrombosis in patients with CVCs, the use of photon-counting CT for this specific evaluation is a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Substudy 1 Inclusion Criteria: * Diseased patients with an indwelling central venous catheter and a clinical indication for autopsy * Informed and signed consent from next of kind Exclusion Criteria: * None Substudy 2 Inclusion Criteria * Living patients with an indwelling central venous catheter who are referred to a CT scan without iv contrast * Informed and signed consent from the patient Exclusion Criteria \- GFR \<15 mL/min/1.73 m2
Where this trial is running
Lund, Skåne County
- Intensive and Perioperative Care. Skåne University Hospital. Lund — Lund, Skåne County, Sweden (RECRUITING)
Study contacts
- Principal investigator: Thomas Kander — Lund University
- Study coordinator: Thomas Kander, PhD
- Email: thomas.kander@med.lu.se
- Phone: +4646171163
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Central Venous Catheter Thrombosis, central venous catheter, thrombosis, photon counting ct