Evaluating the use of dexmedetomidine for laryngoscopic microsurgery without intubation
Evaluation the Efficiency of Intravenous Dexmedetomidine Under Nasal Humidification Rapid Ventilation Device Without Intubation in Laryngoscope Microsurgery
NA · Kaohsiung Veterans General Hospital. · NCT05581485
This study is testing whether using a special medication to help people breathe on their own during laryngoscopic microsurgery can be safer and more effective than traditional intubated anesthesia.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Kaohsiung Veterans General Hospital. (other) |
| Locations | 1 site (Kaohsiung) |
| Trial ID | NCT05581485 on ClinicalTrials.gov |
What this trial studies
This clinical trial compares the effectiveness of laryngoscopic microsurgery (LMS) performed under intubated general anesthesia versus non-intubated anesthesia using high-flow nasal oxygen (HFNO). It aims to assess the safety and feasibility of LMS with non-intubated anesthesia, particularly focusing on the administration of dexmedetomidine to maintain spontaneous breathing. The study will enroll patients aged 20 to 80 who require LMS, dividing them into three groups based on the type of anesthesia received. The goal is to determine if non-intubated anesthesia can provide a clearer surgical field and reduce complications associated with intubation.
Who should consider this trial
Good fit: Ideal candidates are patients aged 20 to 80 years undergoing laryngoscopic microsurgery with an ASA classification of I to III.
Not a fit: Patients with drug dependence, significant organ dysfunction, or those requiring emergency surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance surgical safety and patient comfort during laryngoscopic microsurgery.
How similar studies have performed: While non-intubated anesthesia has been explored in other contexts, the specific combination of dexmedetomidine and LMS under HFNO is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects are between 20-80 years old. * Patients undergoing laryngoscope microsurgery. * Anesthesiologists rated ASA as between I and III. Exclusion Criteria: * Having drug dependence and drinking habits. * Abnormal heart, liver and kidney function. * Allergic reactions to narcotic drugs. * Emergency surgery. * pregnancy. * Refuse to participate. * BMI ≥ 40 kg/m2.
Where this trial is running
Kaohsiung
- Kaohsiung Veterans General Hospital — Kaohsiung, Taiwan (RECRUITING)
Study contacts
- Study coordinator: Yuan Yi Chia, Director
- Email: yychia@vghks.gov.tw
- Phone: 88673422121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Dexmedetomidine, Laryngomicrosurgery, Nonintubation, spontaneous breathing, dexmedetomidine