Clinical trial Recruiting at 3 sites Interventional Ages 18 and up

Evaluating the use of compression stockings for patients needing blood-thinning medication after surgery

Official title: Graduated Compression Stocking as an Adjunct to Extended Duration Pharmacological Thromboprophylaxis for Venous Thromboembolism Prevention

Run by Imperial College London · NCT06166537 · Data updated 2026-11-12

This study is testing if wearing compression stockings can help high-risk surgical patients who are on blood-thinning medication avoid dangerous blood clots.

More Venous Thromboembolism trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment8608 (estimated)
SponsorImperial College London
Academic / other
Locations3 sites (Bristol and 2 other locations)
StatusRecruiting
StartedApril 27, 2024
Main results expectedSeptember 30, 2026
Study endsMarch 31, 2027
Registry record updatedMarch 25, 2026
Trial IDNCT06166537 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older undergoing elective surgery who are assessed as requiring extended duration pharmacological thromboprophylaxis.

Probably not a fit

Patients with contraindications to pharmacological thromboprophylaxis or graduated compression stockings, or those requiring therapeutic anticoagulation, will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates whether adding graduated compression stockings (GCS) to extended duration pharmacological thromboprophylaxis (EDPTP) can further reduce the risk of venous thromboembolism (VTE) in high-risk surgical patients. It addresses the significant issue of hospital-acquired thrombosis, which leads to preventable mortality. The study will compare outcomes between patients receiving GCS and those who do not, aiming to clarify the effectiveness and necessity of GCS in this context. The trial is crucial given the high costs associated with GCS and the potential complications they may cause.

Why it matters

Potential benefit: If successful, this study could lead to more effective prevention strategies for VTE in surgical patients, potentially reducing morbidity and mortality.

How similar studies have gone: Previous studies have shown mixed results regarding the effectiveness of graduated compression stockings, making this trial a necessary investigation into their role alongside pharmacological methods.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults (≥18 years of age)
* Participants undergoing elective surgery; risk assessed as requiring EDPTP

Exclusion Criteria:

* Contraindications to EDPTP or GCS
* Individuals requiring therapeutic anticoagulation e.g., anticoagulation for previous DVT
* Known thrombophilia or thrombogenic disorder

Where it's running

  • North Bristol NHS Trust
    Bristol, United Kingdom
    Recruiting
  • Imperial College Healthcare NHS Trust
    London, United Kingdom
    Recruiting
  • University College London NHS Trust
    London, United Kingdom
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.