Evaluating the use of compression stockings for patients needing blood-thinning medication after surgery
Official title: Graduated Compression Stocking as an Adjunct to Extended Duration Pharmacological Thromboprophylaxis for Venous Thromboembolism Prevention
Run by Imperial College London · NCT06166537 · Data updated 2026-11-12
This study is testing if wearing compression stockings can help high-risk surgical patients who are on blood-thinning medication avoid dangerous blood clots.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 8608 (estimated) |
| Sponsor | Imperial College London Academic / other |
| Locations | 3 sites (Bristol and 2 other locations) |
| Status | Recruiting |
| Started | April 27, 2024 |
| Main results expected | September 30, 2026 |
| Study ends | March 31, 2027 |
| Registry record updated | March 25, 2026 |
| Trial ID | NCT06166537 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older undergoing elective surgery who are assessed as requiring extended duration pharmacological thromboprophylaxis.
✕Probably not a fit
Patients with contraindications to pharmacological thromboprophylaxis or graduated compression stockings, or those requiring therapeutic anticoagulation, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates whether adding graduated compression stockings (GCS) to extended duration pharmacological thromboprophylaxis (EDPTP) can further reduce the risk of venous thromboembolism (VTE) in high-risk surgical patients. It addresses the significant issue of hospital-acquired thrombosis, which leads to preventable mortality. The study will compare outcomes between patients receiving GCS and those who do not, aiming to clarify the effectiveness and necessity of GCS in this context. The trial is crucial given the high costs associated with GCS and the potential complications they may cause.
Why it matters
Potential benefit: If successful, this study could lead to more effective prevention strategies for VTE in surgical patients, potentially reducing morbidity and mortality.
How similar studies have gone: Previous studies have shown mixed results regarding the effectiveness of graduated compression stockings, making this trial a necessary investigation into their role alongside pharmacological methods.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥18 years of age) * Participants undergoing elective surgery; risk assessed as requiring EDPTP Exclusion Criteria: * Contraindications to EDPTP or GCS * Individuals requiring therapeutic anticoagulation e.g., anticoagulation for previous DVT * Known thrombophilia or thrombogenic disorder
Where it's running
-
North Bristol NHS Trust
Bristol, United Kingdom Recruiting -
Imperial College Healthcare NHS Trust
London, United Kingdom Recruiting -
University College London NHS Trust
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Alun H Davies — Imperial College London
- Study coordinator: Alun H Davies
- Email: a.h.davies@imperial.ac.uk
- Phone: 0203 3117371
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
DoACs vs LMWH for blood flow after knee replacement
This study tests whether rivaroxaban, apixaban, or LMWH work differently to support blood flow in the legs after total knee replacement in adults.
-
Prognostic value of the 2026 AHA/ACC PE classification in ED patients with acute PE
This study tests whether the 2026 AHA/ACC five-category PE classification helps predict 30-day major adverse pulmonary embolism events in adults with acute PE presenting to the ED.
-
Screening for blood clots in adults with acute heart failure
This trial tests whether a guideline-based screening approach can detect pulmonary embolism in adults admitted with acute heart failure.
-
Blood test and software to guide treatment for venous thromboembolism
This project tests whether a blood-based ctDNA test combined with a software risk score can predict if VTE will come back in adults with cancer-associated DVT or PE who have finished 3–12 months of anticoagulation.
-
Aspiration thrombectomy with the Symphony or Prodigy devices
This project will try the Symphony and Prodigy aspiration thrombectomy devices to remove arterial, venous, or pulmonary blood clots in adults.
-
Combining European cohort data to find biomarkers that guide treatment for venous thromboembolism
This project combines clinical, biological and imaging data from European patient cohorts to try to find biomarkers that predict clot recurrence, bleeding, or death in people with venous thromboembolism.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.