Evaluating the role of progesterone levels on pregnancy outcomes in frozen embryo transfers
The Importance of Embryo Transfer Day Progesterone Value in Natural Cycle Frozen Embryo Transfers and the Evaluation of the Effect of Rescue Therapy on Pregnancy Outcomes in Patients With Low Progesterone Levels: A Multicentric Randomized Controlled Study.
This study is testing how different levels of progesterone on the day of frozen embryo transfer affect pregnancy success in women aged 20-42 undergoing IVF.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 126 (estimated) |
| Ages | 20 Years to 42 Years |
| Sex | Female |
| Sponsor | Bezmialem Vakif University Academic / other |
| Locations | 3 sites (Istanbul and 2 other locations) |
| Trial ID | NCT05481684 on ClinicalTrials.gov |
What this trial studies
This study investigates how progesterone levels on the day of embryo transfer affect pregnancy outcomes in women undergoing frozen embryo transfers. It includes women aged 20-42 with a BMI under 30 who are receiving IVF treatment for various infertility factors. The study will utilize a controlled ovarian hyperstimulation protocol and assess the impact of low versus normal progesterone levels on the success of the embryo transfer. Participants will be monitored throughout the process, from egg collection to embryo transfer, to evaluate the effectiveness of rescue therapy for those with low progesterone levels.
Who should consider this trial
Good fit: Ideal candidates are women aged 20-42 with a BMI under 30 who are seeking IVF treatment for infertility.
Not a fit: Patients with severe male factor infertility or significant intrauterine structural anomalies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve pregnancy outcomes for women undergoing frozen embryo transfers by optimizing progesterone management.
How similar studies have performed: Other studies have explored the impact of progesterone on fertility outcomes, suggesting that this approach has potential based on previous findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women between the ages of 20-42 who applied to the infertility clinic * BMI\<30 Exclusion Criteria: * Severe male factor (Sperm count \<5 ml/ml, progressively motile sperm count \<10%) * Intrauterine structural anomalies not corrected by surgery * Hydrosalpenx if not underwent surgery * Refusal to participate in the study * cycle cancelation
Where this trial is running
Istanbul and 2 other locations
- Acıbadem Ataşehir Hospital — Istanbul, Turkey (Recruiting)
- Bezmialem Foundation University — Istanbul, Turkey (Recruiting)
- Novaart IVF and Women's Health Center — Istanbul, Turkey (Recruiting)
Study contacts
- Principal investigator: pınar özcan, PhD — Bezmialem Foundation University
- Study coordinator: pınar özcan, PhD
- Email: pinarozcan@hotmail.com
- Phone: +905414031625
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.