Clinical trial Recruiting at 1 site Observational Ages 18 to 100

Evaluating the Prognostic Value of Stress Echocardiography

Official title: The Prognostic Value of Positive Stress Echocardiography and Its Relationship with Invasive Coronary Angiography: the AMPHIPOLIS Study

Run by Hellenic Society of Cardiology · NCT06839755 · Data updated 2026-11-12

This study is testing if positive stress echocardiography results can help predict serious heart problems in people with coronary artery disease or reduced blood flow to the heart.

Quick facts

Study typeObservational
Ages18 Years to 100 Years
SexAll
Enrollment390 (estimated)
SponsorHellenic Society of Cardiology
Academic / other
Locations1 site (Athens, Attica)
StatusRecruiting
StartedOctober 1, 2024
Main results expectedJanuary 31, 2027
Study endsDecember 31, 2027
Registry record updatedFebruary 21, 2025
Trial IDNCT06839755 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with recent positive stress echocardiography indicating myocardial ischemia.

Probably not a fit

Patients with heart failure requiring viability studies, symptomatic valvular disease, or recent acute coronary syndrome may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the prognostic value of positive stress echocardiography in patients with coronary artery disease or myocardial ischemia. It will enroll 390 patients from 25 echocardiography labs in Greece and Cyprus, who will undergo invasive coronary angiography within six weeks of their positive stress echo. The study will monitor participants for major adverse cardiovascular events and cardiovascular death over a follow-up period of at least 12 months. Additionally, it will explore the relationship between stress echo findings and coronary angiography results.

Why it matters

Potential benefit: If successful, this study could improve the prognostic assessment and management of patients with coronary artery disease.

How similar studies have gone: Previous studies have shown promise in using stress echocardiography for prognostic evaluation, making this approach both relevant and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Patients with recent stress echocardiography positive for any extent of myocardial ischemia

Exclusion Criteria:

1. HFrEF requiring viability study.
2. Any symptomatic valvular disease causing symptoms.
3. Established or suspected cardiomyopathy.
4. Concomitant chronic diseases reducing life expectancy (active cancer, severe liver impairment, auto-immune diseases etc).
5. Recent acute coronary syndrome the last week.

Where it's running

  • Hellenic Society of Cardiology
    Athens, Attica, Greece
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.