Clinical trial Recruiting at 1 site Observational Ages 18 to 75

Evaluating the impact of PCI on patients with chronic coronary artery occlusion

Official title: Effect of PCI on Clinical Prognosis of Chronic Coronary Artery Occlusion

Run by The First Affiliated Hospital with Nanjing Medical University · NCT06542653 · Data updated 2026-11-12

This study is testing if a heart procedure called PCI can help people with chronic coronary artery blockages live longer and have fewer serious heart problems compared to those who only receive medication.

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Quick facts

Study typeObservational
Ages18 Years to 75 Years
SexAll
Enrollment258 (estimated)
SponsorThe First Affiliated Hospital with Nanjing Medical University
Academic / other
Locations1 site (Nanjing, Jiangsu)
StatusRecruiting
StartedSeptember 17, 2023
Main results expectedSeptember 17, 2024
Study endsSeptember 17, 2025
Registry record updatedDecember 27, 2024
Trial IDNCT06542653 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients with at least one coronary CTO lesion who are being considered for PCI.

Probably not a fit

Patients with ST-segment elevation myocardial infarction (STEMI), a history of coronary artery bypass grafting (CABG), or other serious conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study assesses the long-term clinical outcomes of patients with chronic total occlusions (CTOs) who underwent percutaneous coronary intervention (PCI) compared to those receiving optimal medical therapy (OMT). Patients treated at the First Affiliated Hospital of Nanjing Medical University between January 2011 and December 2017 were divided into two groups based on their treatment. The primary focus is on major adverse cardiac cerebrovascular events (MACCE), including cardiac death and recurrent myocardial infarction, while secondary outcomes include all-cause mortality. The study aims to determine if PCI can provide better outcomes than OMT alone for CTO patients.

Why it matters

Potential benefit: If successful, this study could lead to improved long-term outcomes for patients with chronic total occlusions.

How similar studies have gone: Previous studies have indicated that PCI can improve outcomes in patients with CTOs, suggesting this approach has been successful in similar contexts.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients with at least one coronary CTO lesion at our hospital in between January 2011 and December 2017

Exclusion Criteria:

* (1) patients with ST-segment elevation myocardial infarction (STEMI)
* (2)a history of coronary artery bypass grafting (CABG)
* (3) cardiogenic shock
* (4) malignant tumor. Patients were referred for PCI based on CTO-related symptoms or evidence of viability, or corresponding ischemia in the area of the CTO artery.

Where it's running

  • The First Affiliated Hospital with Nanjing Medical University
    Nanjing, Jiangsu, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.