Evaluating the impact of PCI on patients with chronic coronary artery occlusion
Official title: Effect of PCI on Clinical Prognosis of Chronic Coronary Artery Occlusion
Run by The First Affiliated Hospital with Nanjing Medical University · NCT06542653 · Data updated 2026-11-12
This study is testing if a heart procedure called PCI can help people with chronic coronary artery blockages live longer and have fewer serious heart problems compared to those who only receive medication.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 258 (estimated) |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Status | Recruiting |
| Started | September 17, 2023 |
| Main results expected | September 17, 2024 |
| Study ends | September 17, 2025 |
| Registry record updated | December 27, 2024 |
| Trial ID | NCT06542653 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with at least one coronary CTO lesion who are being considered for PCI.
✕Probably not a fit
Patients with ST-segment elevation myocardial infarction (STEMI), a history of coronary artery bypass grafting (CABG), or other serious conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study assesses the long-term clinical outcomes of patients with chronic total occlusions (CTOs) who underwent percutaneous coronary intervention (PCI) compared to those receiving optimal medical therapy (OMT). Patients treated at the First Affiliated Hospital of Nanjing Medical University between January 2011 and December 2017 were divided into two groups based on their treatment. The primary focus is on major adverse cardiac cerebrovascular events (MACCE), including cardiac death and recurrent myocardial infarction, while secondary outcomes include all-cause mortality. The study aims to determine if PCI can provide better outcomes than OMT alone for CTO patients.
Why it matters
Potential benefit: If successful, this study could lead to improved long-term outcomes for patients with chronic total occlusions.
How similar studies have gone: Previous studies have indicated that PCI can improve outcomes in patients with CTOs, suggesting this approach has been successful in similar contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with at least one coronary CTO lesion at our hospital in between January 2011 and December 2017 Exclusion Criteria: * (1) patients with ST-segment elevation myocardial infarction (STEMI) * (2)a history of coronary artery bypass grafting (CABG) * (3) cardiogenic shock * (4) malignant tumor. Patients were referred for PCI based on CTO-related symptoms or evidence of viability, or corresponding ischemia in the area of the CTO artery.
Where it's running
-
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Mei Wang
- Email: 1513267113@qq.com
- Phone: 0086 15256095215
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.