Evaluating the impact of high PEEP on breathing effort in ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how high Positive End Expiratory Pressure (PEEP) affects inspiratory effort in patients recovering from Acute Respiratory Distress Syndrome (ARDS). It focuses on patients who are transitioning from passive ventilation to partial ventilatory support and aims to identify those who will benefit from high PEEP application. The study will measure changes in transpulmonary pressure and esophageal pressure swings to determine the effectiveness of high PEEP in reducing inspiratory effort. By understanding these dynamics, the research seeks to improve patient outcomes during recovery from ARDS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Need of invasive mechanical ventilation
* Patients who had fulfill ARDS criteria based on Berlin definition during any time of invasive mechanical ventilation.
* Patient ventilated in pressure support ventilation.
* Time of invasive ventilation expected to be longer than 24 hs after the day of enrollment.

Exclusion Criteria:

* Neuromuscular diseases (e.g., amyotrophic lateral sclerosis, Duchenne Erb)
* previous diagnosis of chronic obstructed pulmonary disease
* not resolved pneumothorax
* bronchopleural fistula
* suspicion of central respiratory drive alteration (e.g., benzodiazepines intoxication).

Where it's running

• Sanatorio Anchorena de San Martin
  San Martín, Buenos Aires, Argentina Recruiting

Study contacts

• Study coordinator: Joaquin Pérez, PT
• Email: licjoaquinperez@hotmail.com
• Phone: +542245505907

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Right‑heart function and heart–lung interaction during ARDS with mechanical ventilation

  This project will follow adults with ARDS on mechanical ventilation to see how positive‑pressure breathing affects the right heart over time and how that relates to circulation.

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• Umbilical‑cord mesenchymal stem cell and secretome therapy for severe ARDS

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  Recruiting Phase 1/2 PT. Prodia Stem Cell Indonesia · Jakarta Pusat, DKI Jakarta · NCT07439848

• Human umbilical cord mesenchymal stem cell injection for moderate to severe ARDS

  This will test whether a single injection of human umbilical cord mesenchymal stem cells can help adults with moderate to severe ARDS that hasn't improved after standard treatment.

  Recruiting Phase 1/2 Changchun Tuohua Pharmaceutical Co., Ltd. · Wuhan, Hubei · NCT07413978

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.