Evaluating the health benefits of two sweet orange varieties in healthy adults
Evaluation of the Antioxidant and Anti-Inflammatory Capacities of the 'Rosy Red Valencia' and 'Olinda Valencia' Sweet Orange Varieties in Healthy Subjects
This study tests whether eating two different types of sweet oranges can improve health by reducing inflammation and oxidative stress in healthy adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 25 Years to 40 Years |
| Sex | All |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Davis, California) |
| Trial ID | NCT06944210 on ClinicalTrials.gov |
What this trial studies
This study evaluates the antioxidant and anti-inflammatory effects of two sweet orange varieties, 'Rosy Red Valencia' and 'Olinda Valencia', in healthy adults. Participants will consume one of the orange varieties twice daily for four weeks, with assessments of oxidative stress, inflammation markers, plasma carotenoid concentrations, and gut health. Blood and fecal samples will be collected to analyze the biological effects of these oranges. The goal is to understand how specific carotenoid profiles in sweet oranges may influence health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy men and women aged 25-40 with a BMI between 21 and 29.9 kg/m².
Not a fit: Patients with a history of significant health issues, such as cardiovascular diseases or autoimmune disorders, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into dietary interventions that enhance health by reducing oxidative stress and inflammation.
How similar studies have performed: While the health benefits of orange consumption are known, this specific comparison of carotenoid-rich and carotenoid-poor varieties is a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * Healthy men and women * Age Range: 25-40 years * Body mass index (BMI) with values between 21 and 29.9 kg\^m2 * Willingness to accept randomization, undergo the testing and intervention procedures, and deliver blood and stool samples * Willingness to refrain from consuming foods rich in lycopene, phytoene, and phytofluene and limit the intake of some polyphenol-rich foods * Willingness to discontinue the use of antioxidant supplements (such as carotenoid, polyphenol supplements), prebiotics and/or probiotics Exclusion Criteria: * Pregnancy/lactation * History of cardiovascular diseases, diabetes, uncontrolled hypertension, heart failure, stroke, liver, gallbladder, kidney, thyroid disease, gastrointestinal, autoimmune disorder, or cancer. * Psychiatric disease that interferes with the understanding and implementation of the intervention * History of eating disorders (such as bulimia nervosa and anorexia nervosa) in the last 5 years * Current smokers * Vegan, vegetarian, or other special diets (e.g., keto, paleo) * Use of antibiotics or laxatives in the previous month * History of substance abuse or alcohol abuse * involvement in a weight loss intervention program within the past month or weight change \> 10% * Self-report of allergic reactions to study products or their phytochemicals.
Where this trial is running
Davis, California
- Nutrition Department, Ragle Facility, University of California Davis — Davis, California, United States (Recruiting)
Study contacts
- Study coordinator: Irena Krga, PhD
- Email: ikrga@ucdavis.edu
- Phone: +1530-752-6554
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.