Evaluating the genetic factors of lipoedema
Evaluation of Lipoedema Tissue Transcriptome
This study is testing the genetic factors behind lipoedema by looking at tissue samples from women with the condition and comparing them to healthy individuals to see what differences exist.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | University Hospital Schleswig-Holstein Academic / other |
| Locations | 1 site (Lübeck, Schleswig-Holstein) |
| Trial ID | NCT05861583 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the molecular mechanisms behind lipoedema, a chronic condition characterized by painful fat accumulation in women. By comparing the RNA expression patterns of subcutaneous tissue from lipoedema patients at various stages to that of healthy individuals, the study seeks to identify genetic and molecular changes associated with the disease. The research also explores the effects of tumescent solutions used during liposuction on fatty tissue. Participants include women aged 18 and older with varying stages of lipoedema and healthy controls with lipohypertrophy.
Who should consider this trial
Good fit: Ideal candidates include women aged 18 and older diagnosed with lipoedema at any stage or healthy women with lipohypertrophy.
Not a fit: Patients with inflammatory conditions in the region of interest or those with HIV or Hepatitis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of lipoedema and inform future treatment options.
How similar studies have performed: While the specific approach of this study is novel, similar studies investigating genetic factors in other conditions have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Lipohypertrophy: tissue from healthy patients (n=20): Consent-capable female patients ≥18 years of age with lipohypertrophy 2. Lipoedema milde stage: tissue from Lipoedema patients with mild stage 1 (n=20): Consent-capable female patients ≥18 years of age with Lipoedema (Stage 1) 3. Lipoedema moderate stage: tissue from Lipoedema patients with moderate stage 2 (n=20): Consent-capable female patients ≥18 years of age with Lipoedema (Stage 2) 4. Lipoedema severe stage: tissue from Lipoedema patients with severe stage 3 (n=20): Consent-capable female patients ≥18 years of age with Lipoedema (Stage 3) Exclusion Criteria: * Inflammation in region of interest, HIV, Hepatitis
Where this trial is running
Lübeck, Schleswig-Holstein
- University of Schleswig-Holstein — Lübeck, Schleswig-Holstein, Germany (Recruiting)
Study contacts
- Study coordinator: Tobias Kisch, MD
- Email: tobias.kisch@uni-luebeck.de
- Phone: 004945150040512
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.