Evaluating the effects of wisdom tooth extraction on gum health

Correlation Between Upper Third Molars Extraction and Upper Second Molars Periodontal Disease: a Prospective Clinical Observational Study

Observational Azienda Ospedaliera Universitaria Senese · NCT06520137

This study looks at how removing impacted upper wisdom teeth affects the gum health of the nearby second molars over time.

Quick facts

Study typeObservational
Enrollment126 (estimated)
Ages19 Years to 64 Years
SexAll
SponsorAzienda Ospedaliera Universitaria Senese Academic / other
Locations1 site (Siena, Italy/SI)
Trial IDNCT06520137 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess how the extraction of impacted maxillary wisdom teeth affects the periodontal conditions of the adjacent second maxillary molars. It will analyze changes in periodontal health over time, focusing on the distal aspect of the second molar. Additionally, the study will evaluate patient-related and tooth-related factors that may influence these periodontal changes. Participants will be monitored for their periodontal health following the extraction procedure.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old with an impacted upper wisdom tooth requiring surgical extraction.

Not a fit: Patients with severe periodontitis, compromised health conditions, or those who have recently taken antibiotics may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide insights into improving periodontal health following wisdom tooth extraction.

How similar studies have performed: While there have been studies on periodontal health post-extraction, this specific observational approach focusing on the distal aspect of the second molar is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age more than 18 years or older
* Presence of an impacted upper wisdom tooth that need to undergo surgical extraction
* Participants need to be able to sign and understand the informed consent and to follow the study-related procedures.

Exclusion Criteria:

* People that have compromised general health conditions (ASA 3, 4, 5, 6)
* Patients that assumed antibiotics in the last 6 months
* Pregnant or breastfeeding women
* Patients who suffer from periodontitis stage III and IV
* Presence of a third molar with incomplete root formation is not taken into account for the surgical extraction.
* Smoker patients

Where this trial is running

Siena, Italy/SI

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Periodontal Diseases
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.