Evaluating the effects of radiotherapy in pediatric and adult patients with childhood cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to assess the short- and long-term toxicity and efficacy of radiotherapy in pediatric and adult patients who have undergone treatment for malignant neoplasms typical of childhood. The study will analyze data from patients treated at the Pediatric Radiotherapy Unit of the CRO in Aviano, focusing on those who received radiation therapy between 1991 and 2030. It will include both retrospective and prospective phases, with specific subgroup analyses based on age, pathology, and radiotherapy techniques, particularly Intensity-Modulated Radiation Therapy (IMRT).

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pediatric, adolescent, and young adult (\<25 years old) patients with malignant neoplasm
* Adult patients (≥25 years) with malignant neoplasm with histology typical of pediatric age but rarely also found in adults and typically treated wherever possible in pediatric protocols (mainly: Central nervous system malignancies such as medulloblastomas and other embryonal tumors, ependymomas, and germ cell tumors; soft tissue and bone sarcomas such as rhabdomyosarcomas and Ewing's sarcomas; nephroblastomas; neuroblastomas)
* Underwent radiation treatment at the Pediatric Radiotherapy Unit of the CRO in Aviano
* Between October 24, 1991, and September 30, 2020, with regard to the retrospective phase of the study, and between October 1, 2020, and September 30, 2030, with regard to the prospective phase of the study
* And who provide informed consent to the study if alive and traceable at the time of enrollment with regard to the retrospective phase of the study and necessarily with regard to the prospective phase. Regarding deceased or alive but untraceable patients enrollable in the retrospective phase of the study, since these are patients who had already given consent to data processing at the time of the radiation therapy being analyzed and registration/enrollment in any specific treatment/research protocols, no new consent is required for the study

Exclusion Criteria:

\- Anything not covered in the inclusion criteria

Where it's running

• Centro di Riferimento Oncologico
  Aviano, Pordenone, Italy Recruiting

Study contacts

• Study coordinator: Maurizio Mascarin, MD
• Email: mascarin@cro.it
• Phone: 0434 659 536

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ozone therapy for refractory pain and quality of life in cancer patients

  This study looks at whether adjuvant ozone therapy can improve quality of life for adults with difficult-to-treat cancer-related symptoms referred to a palliative pain unit.

  Recruiting Hospital Universitario de Gran Canaria Doctor Negrín · Las Palmas de Gran Canaria, Las Palmas · NCT07325851

• Gut microbiome in gynecologic cancer patients with pelvic toxicity

  This study looks at whether gut bacteria profiles relate to pelvic toxicity after cancer treatment and how rectal ozone therapy might affect the gut microbiome and symptoms in women with gynecologic tumors.

  Recruiting at 2 sites Hospital Universitario de Gran Canaria Doctor Negrín · Las Palmas de Gran Canaria, Las Palmas and 1 other locations · NCT07259681

• Curative chest re‑irradiation for thoracic cancers

  This project will try a standardized high‑dose re‑radiation approach for adults with recurrent or new thoracic cancers who previously received chest radiotherapy to see how well it controls disease and what toxicities occur.

  Recruiting University of Aarhus · Aarhus, Jutland · NCT06950073

• First-line bevacizumab versus dexamethasone for symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.

  This trial will test whether first-line bevacizumab or dexamethasone works better at reducing symptoms in adults with symptomatic cerebral radiation necrosis after radiation for high-grade glioma or brain metastases.

  Recruiting at 5 sites Phase 3 The Netherlands Cancer Institute · Amsterdam and 5 other locations · NCT06888817

• Using MR-Linac for precise radiotherapy in cancer treatment

  This study is testing if a new type of radiation therapy using MR-Linac can help cancer patients have better treatment outcomes and improve their quality of life.

  Recruiting The Second Affiliated Hospital of Hainan Medical University · Haikou · NCT06531681

• Post-operative proton radiotherapy for thymus tumors

  This study is testing if proton radiotherapy after surgery can help patients with advanced thymus tumors live longer and feel better, while also looking at any side effects.

  Recruiting Phase 2 Shanghai Proton and Heavy Ion Center · Shanghai, Shanghai Municipality · NCT06311968

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.