Clinical trial Recruiting at 1 site Observational Ages 18 and up

Evaluating the effects of propofol and ketamine on heart stability during intubation

Official title: The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Endotracheal Intubation in Critically Ill Patients: A Prospective Observational Study

Run by Kocaeli City Hospital · NCT06750939 · Data updated 2026-11-12

This study tests how the anesthetics propofol and ketamine affect heart stability in critically ill patients during intubation to see which one is safer.

More Intubation Complication trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment128 (estimated)
SponsorKocaeli City Hospital
Government
Locations1 site (Köseköy, Kocaeli)
StatusRecruiting
StartedJuly 15, 2024
Main results expectedNovember 1, 2025
Study endsNovember 1, 2025
Registry record updatedSeptember 22, 2025
Trial IDNCT06750939 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include critically ill patients over 18 years old who are admitted to the ICU and require endotracheal intubation.

Probably not a fit

Patients who are intubated due to cardiac arrest or those who do not provide consent will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how the anesthetic agents propofol and ketamine affect the risk of cardiovascular collapse in critically ill patients undergoing endotracheal intubation. It focuses on the hemodynamic stability of patients, comparing the incidence of severe hypotension and cardiac arrest associated with each agent. The study also analyzes various shock indices to provide insights into the cardiovascular effects of these induction agents during the intubation process.

Why it matters

Potential benefit: If successful, this study could help identify safer anesthetic practices for critically ill patients, reducing the risk of cardiovascular complications during intubation.

How similar studies have gone: While the specific combination of propofol and ketamine in this context may be novel, previous studies have explored the individual effects of these agents on hemodynamic stability.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged over 18 years
* Patients admitted to the intensive care unit (ICU) who undergo endotracheal intubation during their ICU stay will be included.

Exclusion Criteria:

* Patients who did not provide consent to participate in the study
* Patients intubated due to cardiac arrest
* Patients intubated outside the intensive care unit

Where it's running

  • Kocaeli City Hospital
    Köseköy, Kocaeli, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Comparing two methods for securing intubation tubes

    This study is testing whether a new device for securing breathing tubes works better than the usual method to help prevent complications for patients in intensive care.

    Recruiting Hopital Foch · Suresnes · NCT06533436

  • Comparing video and direct laryngoscopy for intubation by anesthesiology residents

    This study tests whether using video laryngoscopy helps first-year anesthesiology residents do intubations more successfully and safely compared to the traditional direct method.

    Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT06360328

  • Using a Smart Checklist to Improve Pediatric Intubation Safety in ICUs

    This study is testing a new digital checklist to see if it can make tracheal intubations safer for children in intensive care units.

    Recruiting at 6 sites Children's Hospital of Philadelphia · Little Rock, Arkansas and 5 other locations · NCT06085326

  • Using ultrasound to confirm correct intubation in patients

    This study tests if using ultrasound can help doctors make sure they are placing breathing tubes in the right spot during surgery to avoid complications.

    Recruiting Clinica Universidad de Navarra, Universidad de Navarra · Madrid, Madrid · NCT05983666

  • InfasurfAero™ for treating respiratory distress in preterm newborns

    This study is testing a new device that delivers a treatment for breathing problems in preterm newborns to see if it helps them breathe better without needing a breathing tube.

    Recruiting at 10 sites Phase 3 Ony · Phoenix, Arizona and 9 other locations · NCT05960929

  • Improving safety of tracheal intubation in newborns

    This study is testing a new safety plan for intubating newborns in NICUs to see if it can lower the risk of complications during the procedure.

    Recruiting at 7 sites Children's Hospital of Philadelphia · Little Rock, Arkansas and 7 other locations · NCT05838690

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.