Evaluating the effects of propofol and ketamine on heart stability during intubation
The Impact of Propofol and Ketamine on Cardiovascular Collapse During Induction for Endotracheal Intubation in Critically Ill Patients: A Prospective Observational Study
This study tests how the anesthetics propofol and ketamine affect heart stability in critically ill patients during intubation to see which one is safer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 128 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kocaeli City Hospital Government |
| Locations | 1 site (Köseköy, Kocaeli) |
| Trial ID | NCT06750939 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how the anesthetic agents propofol and ketamine affect the risk of cardiovascular collapse in critically ill patients undergoing endotracheal intubation. It focuses on the hemodynamic stability of patients, comparing the incidence of severe hypotension and cardiac arrest associated with each agent. The study also analyzes various shock indices to provide insights into the cardiovascular effects of these induction agents during the intubation process.
Who should consider this trial
Good fit: Ideal candidates include critically ill patients over 18 years old who are admitted to the ICU and require endotracheal intubation.
Not a fit: Patients who are intubated due to cardiac arrest or those who do not provide consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify safer anesthetic practices for critically ill patients, reducing the risk of cardiovascular complications during intubation.
How similar studies have performed: While the specific combination of propofol and ketamine in this context may be novel, previous studies have explored the individual effects of these agents on hemodynamic stability.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged over 18 years * Patients admitted to the intensive care unit (ICU) who undergo endotracheal intubation during their ICU stay will be included. Exclusion Criteria: * Patients who did not provide consent to participate in the study * Patients intubated due to cardiac arrest * Patients intubated outside the intensive care unit
Where this trial is running
Köseköy, Kocaeli
- Kocaeli City Hospital — Köseköy, Kocaeli, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Ömer Emgin, MD
- Email: omermgin@yahoo.com
- Phone: +90 262 225 27 00
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.