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Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 to 65 Men only

Evaluating the effects of metformin on aging in older men

Official title: A Phase II Exploratory Clinical Study Investigating the Geroprotective Effect of Metformin in Middle-aged and Elderly People

Run by Xuanwu Hospital, Beijing · NCT06459310 · Data updated 2026-11-12

This study is testing if the diabetes drug metformin can help older men slow down the aging process.

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years to 65 Years
SexMen only
Enrollment130 (estimated)
SponsorXuanwu Hospital, Beijing
Academic / other
Locations1 site (Beijing)
StatusRecruiting
StartedJune 30, 2024
Main results expectedSeptember 30, 2026
Study endsJuly 31, 2028
Registry record updatedMarch 21, 2025
Trial IDNCT06459310 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are healthy males aged 55 to 65 who can comply with study protocols.

Probably not a fit

Patients with severe chronic diseases or significant health issues may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to assess the effectiveness of oral metformin in slowing the aging process among middle-aged and elderly males. Participants will be divided into two groups, receiving either metformin or a placebo, with treatment administered once daily for one year. The study will also identify sensitive biomarkers of aging and provide insights for future pharmaceutical interventions targeting aging. The research is designed to enhance our understanding of aging and the potential role of metformin in this context.

Why it matters

Potential benefit: If successful, this study could lead to new interventions that slow down the aging process in older adults.

How similar studies have gone: While the approach of using metformin for aging is novel, there have been preliminary studies suggesting potential benefits, indicating a growing interest in this area.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria：

1. Male
2. Age 55-65; 18-28;
3. Able to understand and execute instructions;
4. After reading the consent form, be able to answer questions about the study and demonstrate understanding of the protocol;
5. Be able to participate in regular follow-up visits.

Exclusion Criteria

1. Severe chronic or acute disease: cancer, clinically significant congestive heart failure, chronic obstructive pulmonary disease (COPD), previous or new-onset diabetes, inflammatory state, serum creatinine \>1.5 mg/dl , active liver disease, History of metabolic acidosis, poorly controlled hypertension, epilepsy, recent (within 3 months) cardiovascular events (MI, PTCA, CABG, stroke), severe renal insufficiency, inflammatory bowel disease, persistent glucocorticoids Treatment; neurological diseases such as dementia, AD, PD, etc.; infectious diseases such as HIV, hepatitis, tuberculosis, etc.; severe autoimmune diseases;
2. BMI\<18.5 or BMI\>30;
3. Persistent alcohol or drug abuse;
4. Treatment with drugs known to affect glucose metabolism (other diabetes drugs, systemic glucocorticoids, niacin);
5. Hypersensitivity to metformin or any component of the preparation;
6. Have taken metformin, low-dose aspirin, acarbose, vitamin C in the recent (3 months);
7. Unable to provide informed consent;
8. Other circumstances in which the researcher believes that the physical factors of the participants may adversely affect the research process or results.

Where it's running

  • Xuanwu Hospital Capital Medical University
    Beijing, China     Recruiting

Study contacts

  • Principal investigator: Guoguang Zhao, professor — Xuanwu Hospital, Beijing
  • Study coordinator: Lingling Geng
  • Email: gengll@xwhosp.org
  • Phone: 18510932169

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.