Evaluating the effects of cerebellar tumors on cognitive and motor outcomes during surgery
Perioperative Evaluation of Cerebellar Tumors: Impact of Cerebellar Functional Topography on Cognition and Motor Ataxia
This study is trying to see how the location of brain tumors affects thinking and movement in adults during surgery, comparing those with cerebellar tumors to those with tumors in other areas.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 66 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Duke University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Durham, North Carolina) |
| Trial ID | NCT04463979 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to assess how the location of cerebellar tumors affects cognitive and motor outcomes in patients undergoing surgery. It will compare patients with cerebellar tumors to those with non-cerebellar tumors to determine the prevalence of cerebellar cognitive affective syndrome. The study will involve 66 adult participants, half with cerebellar tumors and half with tumors in other brain locations, to evaluate perioperative assessments and outcomes. The findings could lead to improved surgical strategies and patient care.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with either primary or metastatic cerebellar tumors or non-cerebellar tumors undergoing surgical resection.
Not a fit: Patients under 18, those with non-oncologic cerebellar pathologies, or those with severe performance status may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance perioperative assessments and outcomes for patients with cerebellar tumors.
How similar studies have performed: While similar studies have explored cognitive outcomes in brain tumor patients, this specific focus on cerebellar functional topography is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥18 years of age * Patients with primary cerebellar brain tumors or metastatic brain tumors located in the cerebellum who will undergo surgery for tumor resection, OR with primary non-cerebellar brain tumors or metastatic tumors located in a non-cerebellar brain location who will undergo surgery for tumor resection Exclusion Criteria: * Patients under the age of 18 * Patients with intracranial pathologies (e.g. stroke, vasculitis, infection, developmental anomalies, etc.) outside of the cerebellum * Non-oncologic cerebellar pathologies (e.g. stroke, vasculitis, infection, developmental anomalies, primary cerebellar ataxias, etc.) * Patients who are illiterate, are blind, or do not read or understand English * Patients with a Karnofsky Performance Status score of equal to less than 40
Where this trial is running
Durham, North Carolina
- Duke University Medical Center — Durham, North Carolina, United States (Recruiting)
Study contacts
- Principal investigator: Allan H Friedman, MD — Duke Health
- Study coordinator: Eric W Sankey, M.D.
- Email: eric.sankey@duke.edu
- Phone: 919-970-9408
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.