Evaluating the effect of silver fluoride on dental sealants in children with molar-incisor hypomineralization
The Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.
This study is testing whether using silver fluoride before applying different types of dental sealants can help keep them in place longer on the molars of children with a specific tooth condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 104 (estimated) |
| Ages | 6 Years to 14 Years |
| Sex | All |
| Sponsor | Hacettepe University Academic / other |
| Locations | 1 site (Ankara) |
| Trial ID | NCT06641011 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of glass ionomer and resin fissure sealants applied to permanent molars in children with molar-incisor hypomineralization after the application of silver fluoride. It investigates whether rinsing off or blot-drying the silver fluoride affects the retention of the sealants. The study involves randomizing 216 molars into groups based on the timing of sealant application and the type of sealant used. The goal is to determine the best approach for treating high caries-risk children with this condition.
Who should consider this trial
Good fit: Ideal candidates are children with at least one permanent molar diagnosed with molar-incisor hypomineralization and specific dental conditions requiring sealant application.
Not a fit: Patients with existing restorations, those undergoing orthodontic treatment, or children with systemic conditions requiring ongoing medication may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the retention of dental sealants in children with molar-incisor hypomineralization, leading to better oral health outcomes.
How similar studies have performed: While there is limited data on this specific approach, similar studies have shown promise in improving dental treatment outcomes for high caries-risk populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients and their parents who consent to participate and have signed the informed consent form. * Patients with at least one permanent molar diagnosed with molar incisor hypomineralization based on EAPD guidelines. * Fully erupted teeth with ICDAS I or II lesions that necessitate the application of fissure sealants. * Teeth displaying demarcated opacities on the occlusal surface and at least one additional surface. Exclusion Criteria: * Teeth that have existing restorations or cavities. * Patients currently receiving orthodontic treatment. * Patients who are uncooperative during dental procedures. * Teeth affected by dental fluorosis or enamel defects associated with specific syndromes. * Children with systemic conditions requiring ongoing medication.
Where this trial is running
Ankara
- Hacettepe University Faculty of Dentistry, Department of Pediatric Dentistry — Ankara, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Elif Ballikaya, DDS, PhD — Hacettepe University
- Study coordinator: Elif Ballıkaya, DDS, PhD
- Email: yildirim.elif89@gmail.com
- Phone: +905336401499
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.