Evaluating telavancin in patients with subarachnoid hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the penetration of telavancin into the cerebrospinal fluid (CSF) of patients suffering from spontaneous subarachnoid hemorrhage (SAH). It will involve a prospective cohort of critically ill patients aged 18-65 years who have an actively draining ventriculostomy and a Hunt-Hess score of 1-4. Participants will receive telavancin at a dosage of 10mg/kg every 24 hours for three consecutive doses, with serum and CSF samples collected to evaluate drug concentrations. The study seeks to understand the pharmacokinetics of telavancin in this specific patient population, which may help in treating resistant CNS infections.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult aged 18-85 years
* Actively draining ventriculostomy

Exclusion Criteria:

* history of hypersensitivity to telavancin or similar agents
* reduced renal function (estimated creatinine clearance \< 50/ml) at the time of consent
* severe anemia (hemoglobin \< 7gm/dl)
* vulnerable population (pregnant, prisoner)
* concomitant antimicrobial therapy

Where it's running

• University of Kentucky
  Lexington, Kentucky, United States Recruiting

Study contacts

• Principal investigator: Aaron M Cook, PharmD — University of Kentucky
• Study coordinator: Aaron Cook, PharmD
• Email: amcook0@email.uky.edu
• Phone: 859-323-9258

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.