Evaluating SHR-A1811 for Ovarian Cancer Treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This open-label Phase 3 study aims to assess the safety and efficacy of SHR-A1811 in patients diagnosed with ovarian cancer. Participants will receive SHR-A1811 along with standard chemotherapy agents such as Paclitaxel, Doxorubicin, Gemcitabine, and Topotecan. The study will include subjects with measurable disease and will monitor their response to treatment over time. The goal is to determine if SHR-A1811 can improve outcomes for these patients compared to existing therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. The subjects voluntarily joined the study and signed the Informed consent forms (ICF).
2. Measurable disease, as defined by RECIST v1.1.
3. The Eastern Cancer Cooperative Group (ECOG) performance status of 0 or 1.
4. Life expectancy ≥ 12 weeks.

Exclusion Criteria:

1. Symptomatic, untreated or active central nervous system metastases.
2. Have uncontrolled or severe cardiovascular disease.
3. With any active autoimmune disease or history of autoimmune disease.
4. Patients with active hepatitis B or hepatitis C.
5. Severe infections prior to initiation of study treatment.
6. Patients with active tuberculosis.

Where it's running

• Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting
• Qilu Hospital of Shandong University
  Jinan, Shandong, China Recruiting

Study contacts

• Study coordinator: Yuanchao Wang
• Email: yuanchao.wang@hengrui.com
• Phone: 0518-82342973

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.