Evaluating sensorimotor function to predict ACL graft rupture
Sensorimotor Function as Predictor for Graft Rupture After Anterior Cruciate Ligament Reconstruction: A Prospective Cohort Study (STOP Graft Rupture)
Umeå University · NCT04162613
This study is trying to see if measuring balance and strength in young people who had ACL surgery can help predict if their graft will tear again or if they'll get hurt on the other knee.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 15 Years to 35 Years |
| Sex | All |
| Sponsor | Umeå University (other) |
| Locations | 1 site (Umeå) |
| Trial ID | NCT04162613 on ClinicalTrials.gov |
What this trial studies
This observational study follows young individuals aged 15-35 who have undergone anterior cruciate ligament (ACL) reconstruction. It aims to determine if baseline sensorimotor function, assessed through measures like hop performance and muscle strength, can predict outcomes such as graft rupture, contra-lateral ACL injury, and the ability to return to previous activity levels within three years post-surgery. The study will utilize logistic regression models to analyze the influence of various muscle function metrics on these outcomes, with a target enrollment of 200 participants.
Who should consider this trial
Good fit: Ideal candidates are young athletic individuals aged 15-35 who are 8-16 months post ACL reconstruction.
Not a fit: Patients with previous ACL injuries in the same or opposite knee, or those with overriding knee conditions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify individuals at higher risk for ACL graft failure, allowing for targeted rehabilitation strategies.
How similar studies have performed: While similar studies have explored the relationship between sensorimotor function and ACL injuries, this specific predictive approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 8-16 months after ACL reconstruction * With or without associated injuries to other structures of the knee (e.g., collateral ligament(s), meniscal injury) * Age 15-35 years. Exclusion Criteria: * ACL injury other knee and previous ACL injury index knee * Diseases or disorders overriding the knee condition (e.g., neurological or rheumatological disease) * Not understanding the languages of interest (any Scandinavian language or English).
Where this trial is running
Umeå
- UMotion laboratory — Umeå, Sweden (RECRUITING)
Study contacts
- Principal investigator: Anna Cronström, PhD — Umeå University
- Study coordinator: Anna Cronström, PhD
- Email: anna.cronstrom@umu.se
- Phone: +46707488770
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Anterior Cruciate Ligament Injuries, anterior cruciate ligament injury, re-injury, muscle function, functional performance, rehabilitation, physiotherapy, sensorimotor control