Evaluating saliva markers in patients with different periodontal diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to detect levels of Adseverin, 1-alpha Defensin, and sRANKL in saliva samples from individuals with varying periodontal health, including those with periodontitis, gingivitis, and healthy gums. A total of 60 systemically healthy non-smokers will participate, providing saliva samples and undergoing full-mouth clinical periodontal assessments. The study will utilize enzyme-linked immunosorbent assay (ELISA) to analyze the correlation between these salivary markers and clinical parameters of periodontal diseases.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Systemically healthy (The determination of healthy volunteers will be based on the statements of the patients in the anamnesis. No additional examinations will be made.) At least twenty permanent teeth in the mouth Non-smoker No medication for continuous use Those who have not used antibiotics, anti-inflammatory and systemic corticosteroid drugs in the last 6 months.

Not in pregnancy or lactation period. For the periodontitis group that has not received periodontal treatment in the last 6 months For the periodontitis group; According to the evaluation made in 6 regions of each tooth, individuals with 30% or more bleeding on probing area, at least 2 teeth not adjacent to each quarter jaw with a depth of 5 mm or more and 4 mm or more attachment loss, coronal 1/3 and more on radiography (horizontal and / or vertical) bone loss For the gingivitis group; According to the evaluation made in 6 regions of each tooth, individuals with 10% or more bleeding on probing area, having a probing depth of less than 4mm and no attachment loss For healthy group; According to the evaluation made in 6 regions of each tooth,individuals with less than 10% bleeding on probing area, having a probing depth less than 4mm and no loss of attachment were included in the study.

Exclusion Criteria:

Any oral or systemic disease Regularly using a systemic medication During pregnancy or lactation Received periodontal treatment within the last 6 months. Those who received antibiotic, anti-inflammatory or systemic corticosteroid medication in the last 6 months Smokers are not included in the study

Where it's running

• Izmir Katip Çelebi University Department of Periodontology
  İzmir, Çiğli, Turkey Recruiting

Study contacts

• Study coordinator: Ayşe Efe
• Email: efeayse421@gmail.com
• Phone: +905076372147

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effect of Periodontal Therapy on Gut Microbes and Inflammation in People with Inflammatory Bowel Disease

  This study tests whether treating gum disease in people with inflammatory bowel disease can influence the gut microbiome and markers of systemic inflammation.

  Recruiting University of Turin, Italy · Turin, Turin · NCT07905859

• Bacterial Diversity in Gum Health With Fixed vs Removable Retainers After Braces

  This study tests the gum microbiome and gum health in adults after braces, comparing fixed lingual retainers to removable Essix retainers.

  Recruiting Universidad de Murcia · Murcia · NCT07718061

• Hyperuricemia and gum disease: is uric acid linked to bone loss in periodontitis?

  This observational study tests whether high uric acid levels are related to periodontitis and alveolar bone loss in adults.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07666126

• See if periodontal treatment improves chewing ability and oral quality of life

  This study tests whether treating periodontitis improves how well people can chew and how they feel about their oral health.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07651579

• Vitamin D and the body's anti-inflammatory response in gum disease

  This study tests whether vitamin D can modulate the body's anti-inflammatory response in people with gum disease.

  Recruiting Recep Tayyip Erdogan University Training and Research Hospital · Rize · NCT07636733

• Candida albicans and periodontitis in Syrian patients

  This project will test whether Candida albicans is commonly present in the gum pockets of Syrian adults with chronic periodontitis.

  Recruiting Al-Hawash Private University · Homs · NCT07574827

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.