Evaluating risk factors for prolonged mechanical ventilation in ICU patients

Risk Factors for Prolonged Mechanical Ventilation in Elevated Mean Airway Pressure Based on a Remote Ventilation Monitoring Platform

This study is trying to find out what factors make it more likely for ICU patients with high airway pressure to need longer help with breathing machines.

Quick facts

• Study type: Observational
• Enrollment: 400 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Peking Union Medical College Hospital (Academic / other)
• Locations: 4 sites (Peking, Beijing and 3 other locations)
• Trial ID: NCT05902403 on ClinicalTrials.gov

What this trial studies

This multicentric observational study aims to identify risk factors associated with prolonged mechanical ventilation in patients with elevated mean airway pressure in the ICU. Utilizing a remote ventilation monitoring system, the study will analyze dynamic ventilation parameters to assess their relationship with outcomes such as barotrauma and length of ICU stay. The focus is on patients with an average airway pressure of at least 10 cmH2O upon admission, who are at higher risk for ventilator-induced lung injury. The study seeks to enhance understanding of patient-ventilator interactions and improve clinical outcomes.

Who should consider this trial

Good fit: Ideal candidates are patients receiving invasive mechanical ventilation with an average mean airway pressure of 10 cmH2O or higher within the first 24 hours of ICU admission.

Not a fit: Patients expected to receive ECMO treatment, those with a Glasgow Coma Scale score less than 8, or those requiring ventilation due to neuromuscular diseases may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies for patients requiring mechanical ventilation, potentially reducing complications and ICU stay.

How similar studies have performed: While studies have explored mechanical ventilation parameters, this approach utilizing a remote monitoring system for dynamic assessment is relatively novel.

Eligibility criteria

Inclusion Criteria:

* Patients receiving invasive mechanical ventilation, an average mean airway pressure ≥10 cmH2O for 6 consecutive hours within the first 24 hours of ICU admission.

Exclusion Criteria:

* Currently receiving or expected to receive ECMO treatment within 24 hours;
* Glasgow Coma Scale (GCS) score less than 8 due to cardiac arrest, traumatic brain injury, or acute stroke;
* Requiring invasive mechanical ventilation due to neuromuscular diseases;
* Exceeding 24 hours from ICU admission to connection to the remote monitoring system.

Where this trial is running

Peking, Beijing and 3 other locations

• Peking Union Medical College Hospital — Peking, Beijing, China (Recruiting)
• Qilu Hospital of Shangdong University — Jinan, Shandong, China (Not_yet_recruiting)
• Sichuan Provincial People's Hospital — Chengdu, Sichuan, China (Not_yet_recruiting)
• Shanghai Tenth People's Hospital — Shanghai, China (Not_yet_recruiting)

Study contacts

• Study coordinator: Yun Long, Dr

Conditions Mechanical Ventilation Pressure High; Intensive Care Unit