Evaluating ovarian reserve in women with multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the ovarian reserve of women diagnosed with multiple sclerosis compared to a control group of healthy women aged 25 to 35. The evaluation will be conducted using Anti-Mullerian Hormone (AMH) levels and Antral Follicle Count (AFC) through ultrasound imaging. The study seeks to determine if multiple sclerosis negatively impacts ovarian reserve, potentially leading to fertility preservation considerations for affected patients. It is a monocentric study conducted at Pellegrin Hospital in Bordeaux.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Reproductive women between 25 and 35 years old ;
* MS Patient : Diagnosis of multiple sclerosis based on McDonald Criteria 2017;
* French-speaking, without comprehension disorders ;
* being affiliated to health insurance ;
* Willing to participate and to sign informed consent.

Exclusion Criteria:

* History of ovarian surgery (cystectomy, annexectomy) ;
* Turner Syndrome ;
* fragile X messenger ribonucleoprotein 1 (FMR1) premutation ;
* Endometriosis with a risk of ovarian reserve alteration ;
* History of chemotherapy or pelvic radiotherapy ;
* Pregnant or breastfeeding women ;
* patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).

Where it's running

• CHU de Bordeaux - service de neurologie
  Bordeaux, France Recruiting

Study contacts

• Principal investigator: Valérie BERNARD, MD — University Hospital, Bordeaux
• Study coordinator: Valérie BERNARD, MD
• Email: valerie.bernard@chu-bordeaux.fr
• Phone: (0)5 56 79 56 79

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.