Home › Trials › NCT06993792

Evaluating Orforglipron for Weight Management in People with Obesity or Overweight

A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes

PHASE3 · Eli Lilly and Company · NCT06993792

This study is testing if orforglipron can help people with obesity or overweight manage their weight better than a placebo, including those with and without type 2 diabetes.

Quick facts

PhasePHASE3
Study typeInterventional
Enrollment1200 (estimated)
Ages18 Years and up
SexAll
SponsorEli Lilly and Company (industry)
Locations89 sites (Tucson, Arizona and 88 other locations)
Trial IDNCT06993792 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to assess the safety and efficacy of orforglipron in individuals with obesity or overweight, both with and without type 2 diabetes. Participants will undergo a screening process lasting about four weeks before being assigned to one of two studies based on their diabetes status. The trial will compare the effects of orforglipron against a placebo to determine its effectiveness in managing weight and related health conditions.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals with obesity or overweight, with or without type 2 diabetes.

Not a fit: Patients who are not overweight or do not have obesity may not receive any benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new option for weight management in individuals struggling with obesity or overweight, potentially improving their overall health.

How similar studies have performed: Other studies have shown promise in using similar approaches for weight management, indicating potential for success in this trial.

Eligibility criteria

Show full inclusion / exclusion criteria 
There are no specific eligibility criteria for the Master Protocol.

* See study GZP1 for eligibility criteria relevant to participants with obesity and overweight without type 2 diabetes
* See study GZP2 for eligibility criteria relevant to participants with type 2 diabetes

Where this trial is running

Tucson, Arizona and 88 other locations

+39 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Obesity, Overweight, Type 2 Diabetes

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.