Evaluating Oliceridine for Pain Relief After Orthopedic Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness and safety of oliceridine in managing moderate to severe acute pain following orthopedic surgery. Participants will be randomly assigned to receive either high-dose or low-dose oliceridine, or hydromorphone, and their pain levels will be monitored using a numerical evaluation scale. The study aims to compare the analgesic effects of these treatments to identify optimal pain management strategies. The trial is conducted under controlled conditions with standardized anesthesia protocols.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. elective orthopedic surgery under general anesthesia.
2. The patient can communicate normally and has the correct expression of pain

Exclusion Criteria:

1. Patients with advanced tumor
2. Other acute and chronic pain conditions are present
3. Severely obese (30 kg/m2)
4. Pregnant or lactating women
5. Allergy to opioids
6. Sleep apnea syndrome
7. Long-term opioid treatment
8. Patients with mental and nervous system diseases, gastrointestinal obstruction, chronic obstructive pulmonary disease or pulmonary heart disease, cardiovascular disease
9. Abnormal liver function during screening
10. Abnormal renal function during screening

Where it's running

• The Fourth Affiliated Hospital of Zhejiang University School of Medicine
  Yiwu, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Dongmei Ma
• Email: 8019111@zju.edu.cn
• Phone: +8615267358077

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.