Evaluating Oliceridine for Pain Relief After Orthopedic Surgery
Efficacy and Safety of Oliceridine for Moderate to Severe Acute Pain After Orthopedic Surgery
This study is testing whether a new pain medication called oliceridine can help people with moderate to severe pain after orthopedic surgery feel better compared to a standard painkiller.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 162 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | The Fourth Affiliated Hospital of Zhejiang University School of Medicine Academic / other |
| Locations | 1 site (Yiwu, Zhejiang) |
| Trial ID | NCT06320041 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness and safety of oliceridine in managing moderate to severe acute pain following orthopedic surgery. Participants will be randomly assigned to receive either high-dose or low-dose oliceridine, or hydromorphone, and their pain levels will be monitored using a numerical evaluation scale. The study aims to compare the analgesic effects of these treatments to identify optimal pain management strategies. The trial is conducted under controlled conditions with standardized anesthesia protocols.
Who should consider this trial
Good fit: Ideal candidates are adults undergoing elective orthopedic surgery who can communicate their pain levels effectively.
Not a fit: Patients with advanced tumors, chronic pain conditions, or those on long-term opioid treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective and safer pain management option for patients recovering from orthopedic surgery.
How similar studies have performed: Previous studies have shown promise in using oliceridine for pain management, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. elective orthopedic surgery under general anesthesia. 2. The patient can communicate normally and has the correct expression of pain Exclusion Criteria: 1. Patients with advanced tumor 2. Other acute and chronic pain conditions are present 3. Severely obese (30 kg/m2) 4. Pregnant or lactating women 5. Allergy to opioids 6. Sleep apnea syndrome 7. Long-term opioid treatment 8. Patients with mental and nervous system diseases, gastrointestinal obstruction, chronic obstructive pulmonary disease or pulmonary heart disease, cardiovascular disease 9. Abnormal liver function during screening 10. Abnormal renal function during screening
Where this trial is running
Yiwu, Zhejiang
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine — Yiwu, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Dongmei Ma
- Email: 8019111@zju.edu.cn
- Phone: +8615267358077
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.