Evaluating non-surgical treatment effects on gum disease
Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on miRNome in Gingival Tissues
This study is testing how non-surgical gum disease treatments affect patients with periodontitis by looking at changes in certain molecules in their gum fluid.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University of Catania Academic / other |
| Locations | 1 site (Catania) |
| Trial ID | NCT06382935 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of non-surgical periodontal treatment on patients with periodontitis, focusing on changes in the miRNome found in gingival crevicular fluid. The study employs a double-blind randomized-controlled design, comparing outcomes between patients receiving treatment and healthy controls. A total of 60 participants will be assessed for clinical and periodontal parameters before and after treatment using minimally invasive techniques. The goal is to better understand the molecular impacts of periodontal therapy.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with periodontitis.
Not a fit: Patients who have received periodontal treatment or are currently using antibiotics, NSAIDs, or immunosuppressants may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved non-surgical treatment options for patients with periodontitis.
How similar studies have performed: While there have been studies on periodontal treatments, this specific approach focusing on miRNome is relatively novel and not extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of Periodontitis Exclusion Criteria: * Periodontal treatment * Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months * Pregnancy
Where this trial is running
Catania
- AOU Policlinico G. Rodolico — Catania, Italy (Recruiting)
Study contacts
- Principal investigator: Gaetano Isola — Università degli Studi di Catania
- Study coordinator: Gaetano Isola
- Email: gaetano.isola@unict.it
- Phone: 0953785652
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.