Evaluating new radiation techniques for heart imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess new methods of computed tomography (CT) imaging that reduce radiation exposure while maintaining image accuracy for diagnosing coronary disease. Participants will undergo a CT scan of the heart and blood vessels, potentially using a contrast agent to enhance image quality. The study will involve screening participants through physical exams and medical history, along with blood tests to evaluate kidney function. The goal is to determine the effectiveness of these innovative imaging techniques in producing reliable results.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

  1. Clinical indication for a coronary CT angiography exam
  2. Age equal to or greater than 18 years
  3. Able to understand and willing to sign the Informed Consent Form
  4. Able and willing to provide follow-up information

EXCLUSION CRITERIA:

1. Pregnancy
2. If receiving intravenous contrast, severe renal excretory dysfunction, estimated glomerular filtration rate \< 30 mL/min/1.73m2 body surface area according to the Modification of Diet in Renal Disease criteria or as reported by the clinical lab. Glomerular filtration rate will be estimated using the 2021 CK-EPI equation that eliminate the use of race coefficient as reported in CRIS.

Screen Failures: Subjects who are screen failures can be re-enrolled once they meet eligibility criteria. Rescreened participants will be assigned the same participant number as for the initial screening.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Marcus Y Chen, M.D. — National Heart, Lung, and Blood Institute (NHLBI)
• Study coordinator: Margaret C Lowery, R.N.
• Email: peg.lowery@nih.gov
• Phone: (301) 412-9255

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tailored digital support to cut sedentary time in long-term cardiac rehab

  In adults in a long-term cardiac rehabilitation program, this study tests whether a personalized behavioural program with digital tools can reduce daily sitting time.

  Recruiting University of Lisbon · Lisbon, Lisbon District · NCT07910812

• Predicting how coronary artery disease progresses in adults 45 and younger

  This project will try to build prediction models using coronary CT scans and health data from people aged 18–45 to see who is more likely to have plaque get worse over time.

  Recruiting Fu Wai Hospital, Beijing, China · Beijing · NCT07316452

• Freesolve resorbable magnesium scaffold vs. Xience stent for up to two new heart artery lesions

  This trial tests whether the Freesolve resorbable magnesium scaffold works as well as the Xience drug-eluting stent for treating up to two new coronary artery lesions in adults.

  Recruiting at 3 sites Teleflex · Washington D.C., District of Columbia and 2 other locations · NCT07258290

• Italian Cardiac Rehabilitation Registry for Coronary Disease and Heart Failure

  This registry collects real-world information to see how cardiac rehabilitation programs work for adults recovering from coronary disease or heart failure across Italy.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Milan · NCT07094737

• Orbital atherectomy versus standard balloon strategy for calcified coronary bifurcation lesions

  This study tests whether using orbital atherectomy before stenting helps adults with moderately or severely calcified coronary bifurcation lesions get better stent results than the standard balloon-first approach.

  Recruiting at 9 sites Fundación EPIC · Alicante and 8 other locations · NCT06736899

• Healthy Nordic diet's effects on heart disease

  This study is testing if following a Healthy Nordic diet can help people with coronary heart disease improve their heart health over 18 months.

  Recruiting Uppsala University · Uppsala · NCT06701968

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.