Evaluating new markers for faster diagnosis of acute coronary syndromes
Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study
This study is testing new blood markers to see if they can help doctors quickly diagnose heart problems in patients with chest pain who have had symptoms for less than 12 hours.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 13 sites (Brno and 12 other locations) |
| Trial ID | NCT00470587 on ClinicalTrials.gov |
What this trial studies
This observational study aims to improve the triage process for patients presenting with acute chest pain in emergency departments by testing new cardiac markers alongside meticulous patient history. It focuses on patients who have experienced symptoms within the last 12 hours and compares the effectiveness of these novel markers to the current gold standard, high-sensitivity cardiac troponin T. Blood samples will be collected and analyzed to determine the potential for quicker detection or exclusion of acute myocardial infarction (AMI). Follow-up assessments will be conducted at multiple intervals to monitor patient outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults presenting to the emergency department with chest pain or symptoms suggestive of myocardial ischemia within the last 12 hours.
Not a fit: Patients under 18 years old, those in cardiogenic shock, or individuals with terminal kidney disease requiring dialysis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to faster and more accurate diagnoses of acute myocardial infarction, potentially saving lives and reducing healthcare costs.
How similar studies have performed: Previous studies have shown promise with similar approaches using novel cardiac markers, but this specific evaluation in a large cohort is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting to the emergency department * Typical angina pectoris or other thoracic sensations that are suspected to be caused by myocardial ischemia * Symptoms at rest or minor exertion * Onset of symptoms within the last 12 hours prior to presentation * Written informed consent Exclusion Criteria: * Age \< 18 years * Cardiogenic shock * Terminal kidney disease requiring regular dialysis
Where this trial is running
Brno and 12 other locations
- Masaryk University Brno — Brno, Czechia (Recruiting)
- Emergency Department San Martino Hospital — Genova, Italy (Recruiting)
- Medical University of Silesia — Zabrze, Poland (Recruiting)
- Hospital Clinic of Barcelona — Barcelona, Spain (Recruiting)
- Hospital del Mar — Barcelona, Spain (Active_not_recruiting)
- Hospital Clinico San Carlos — Madrid, Spain (Recruiting)
- University Hospital of Basel — Basel, Switzerland (Recruiting)
- Kantonsspital Baselland, Standort Bruderholz — Bottmingen, Switzerland (Completed)
- Kantonsspital Baselland, Standort Liestal — Liestal, Switzerland (Recruiting)
- Klinik St. Anna — Luzern, Switzerland (Completed)
- Kantonsspital Olten — Olten, Switzerland (Recruiting)
- Spital Limmattal — Schlieren, Switzerland (Completed)
- Universitätsspital Zürich — Zurich, Switzerland (Recruiting)
Study contacts
- Principal investigator: Christian Mueller, MD — University Hospital of Basel
- Study coordinator: Christian Mueller, MD
- Email: christian.mueller@usb.ch
- Phone: 0041-61-2652525
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.