Evaluating neuropeptide levels in meningitis patients
Evaluation of the Levels of Calcitonin Gene-related Peptide and Substance P in Patients With Post-operative Meningitis
This study is testing if certain proteins in the blood and spinal fluid can help doctors better diagnose and understand the outcomes for adults with meningitis related to external ventricular catheters in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 51 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Akdeniz University Academic / other |
| Locations | 1 site (Antalya) |
| Trial ID | NCT06510751 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on adult patients with suspected meningitis related to external ventricular catheters in the Intensive Care Unit. It aims to analyze the levels of calcitonin gene-related peptide (CGRP) and substance P in blood and cerebrospinal fluid (CSF) samples taken at various stages of the disease. The study will also assess clinical parameters such as the patient's state of consciousness, organ failure, and infection status, alongside routine laboratory tests and imaging findings. The goal is to identify reliable biomarkers that can improve the diagnosis and prognosis of postoperative meningitis.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are in the Intensive Care Unit with suspected meningitis related to CSF drainage systems.
Not a fit: Patients under 18 years of age or those with suspected meningitis who have not undergone neurosurgical operations and lack a CSF drainage catheter will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and prognostic tools for patients with meningitis, potentially reducing mortality and morbidity rates.
How similar studies have performed: There are very few studies investigating CGRP and substance P levels in this context, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years and over * Patients followed up in the intensive care unit with suspected meningitis Exclusion Criteria: * Patients under 18 years of age * Patients with suspected meningitis in the intensive care unit who have not undergone neurosurgical operation and do not have CSF drainage catheter
Where this trial is running
Antalya
- Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey — Antalya, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Melike Cengiz, MD,Professor
- Email: melikecengiz@yahoo.com
- Phone: +902422496231
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.