Evaluating nerve stiffness in carpal tunnel syndrome patients receiving therapy
Pilot Study Evaluating the Elasticity and Shear Wave Modulus (Stiffness) of the Median Nerve in Patients With Mild to Moderate Idiopathic Carpal Tunnel Syndrome Receiving OMT and Conservative Therapy
This study is testing if a combination of therapy and treatment can improve the stiffness and flexibility of the median nerve in people with mild to moderate carpal tunnel syndrome.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Kettering Health Network Academic / other |
| Locations | 1 site (Dayton, Ohio) |
| Trial ID | NCT06150443 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to assess the elasticity and stiffness of the median nerve in patients diagnosed with mild to moderate carpal tunnel syndrome. Participants will receive osteopathic manipulative therapy alongside conservative treatment, with the goal of quantifying any changes in nerve properties. The study will utilize advanced imaging techniques to measure the shear wave modulus of the median nerve before and after treatment. This approach seeks to provide insights into the effectiveness of the therapies on nerve health.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with unilateral or bilateral mild to moderate carpal tunnel syndrome based on recent EMG findings.
Not a fit: Patients with severe carpal tunnel syndrome, recent wrist trauma, or systemic diseases that affect nerve health may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with carpal tunnel syndrome.
How similar studies have performed: While there is limited data on the specific combination of therapies being tested, similar studies have shown promise in evaluating nerve properties in related conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of unilateral or bilateral mild to moderate carpal tunnel syndrome, based on recent EMG findings Exclusion Criteria: * History of undergoing recent physical therapy for treatment of carpal tunnel syndrome * History of wrist trauma or surgery * Hypothyroidism * Severe CTS that has progressed to muscle atrophy * Systemic disease or condition including but not limited to diabetes mellitus, thyroid disorders, rheumatoid disorders, Paget's bone disease, gout, myxedema, multiple myeloma, acromegaly, hepatic disease, dialysis patients, or other diseases or conditions in which peripheral neuropathies are common. * Secondary cause of CTS such as a ganglion cyst, mass, or an accessory muscle shown by US or MRI of the affected wrist. * Bifid median nerve as shown by US or MRI of the affected wrist * pregnant or recently postpartum
Where this trial is running
Dayton, Ohio
- Kettering Health — Dayton, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Roland Gazaille, DO — Kettering Health
- Study coordinator: Roland Gazaille, DO
- Email: roland.gazaille@ketteringhealth.org
- Phone: 937-297-6307
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.