Evaluating meningioma properties using 3D magnetic resonance elastography
Evaluation of Meningioma Mechanical Properties and Histological Features Using Three-Dimensional Magnetic Resonance Elastography
This study is testing if a new type of MRI can help doctors understand the stiffness and attachment of meningiomas in patients before surgery to improve planning and safety.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Shengjing Hospital Academic / other |
| Locations | 1 site (Shenyang, Liaoning) |
| Trial ID | NCT06955208 on ClinicalTrials.gov |
What this trial studies
This prospective study aims to assess the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in evaluating the stiffness and adhesion of meningiomas in patients undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to establish MRE as a noninvasive imaging biomarker for surgical planning and risk stratification. Approximately 300 patients with confirmed meningioma will undergo standard MRI and additional 3D MRE scanning, with intraoperative findings systematically recorded for analysis.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for elective resection of radiologically confirmed meningiomas.
Not a fit: Patients with metallic implants, severe claustrophobia, or those unable to tolerate MRE may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance surgical planning and outcomes for patients with meningioma by providing critical biomechanical information preoperatively.
How similar studies have performed: While the use of MRE in this context is innovative, similar imaging techniques have shown promise in other tumor types, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients undergoing meningeoma resection surgery are eligible for inclusion in the study cohort. Exclusion Criteria: * Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who can not remove dentures, insulin pumps, or contraceptive rings) * Pregnant women in the first trimester (within three months) * Patients with severe claustrophobia or anxiety * Patients with severe fever * Patients who can not tolerate MRE * Patients with vascular malformations and aneurysms. * Patients who do not sign an informed consent
Where this trial is running
Shenyang, Liaoning
- Shengjing Hospital — Shenyang, Liaoning, China (Recruiting)
Study contacts
- Principal investigator: Yu Shi, MD — Shengjing Hospital
- Study coordinator: Yu Shi, MD
- Email: 18940259980@163.com
- Phone: +86 189 4025 9980
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.