Evaluating Losartan for treating coarctation of the aorta and high blood pressure
Official title: A Phase III, Randomized, Double-Blind, Placebo Controlled Clinical Trial Evaluating the Benefits and Mechanism Of Action Of Angiotensin-II Receptor Blocker On Cardiovascular Remodeling In Patients With Repaired Coarctation Of Aorta
Run by Mayo Clinic · NCT06150560 · Data updated 2026-11-12
This study is testing if the medication Losartan can help people who have high blood pressure and a heart condition called coarctation of the aorta feel better compared to another medication or a placebo.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Status | Recruiting |
| Started | April 1, 2024 |
| Main results expected | June 1, 2028 |
| Study ends | June 1, 2028 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT06150560 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 or older with a history of coarctation of the aorta repair and specific blood pressure criteria.
✕Probably not a fit
Patients currently on beta blocker therapy, pregnant or lactating, or with severe cardiovascular conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to assess the effectiveness and underlying mechanisms of Losartan, an angiotensin-II receptor blocker, in patients with coarctation of the aorta and hypertension. Participants will receive either Losartan, Amlodipine, or a placebo to determine the best treatment approach. The study focuses on individuals who have previously undergone repair for coarctation of the aorta and have specific blood pressure measurements. The goal is to improve cardiovascular remodeling and overall patient outcomes.
Why it matters
Potential benefit: If successful, this study could provide a new effective treatment option for patients with coarctation of the aorta and hypertension.
How similar studies have gone: Previous studies have shown promise in using angiotensin-II receptor blockers for hypertension, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * B/S1 hypertension * SBP 100-139 average based on 3 office measurements. * Age 18 or Older * Previous COA Repair Exclusion Criteria: * Currently on beta blocker (BB) therapy * Pregnancy/lactating * eGFR\<30 * Hyperkalemia (serum potassium \>5.5mmol/L) * Severe Aortic or Mitral valve stenosis or regurgitation * Epicardial CAD diagnosis * Received antihypertensive medications within the past year
Where it's running
-
Mayo Clinic in Rochester
Rochester, Minnesota, United States Recruiting
Study contacts
- Principal investigator: Alexander Egbe, MBBS, MPH — Mayo Clinic
- Study coordinator: ACHD Research Program
- Email: RSTACHDRESPRG@mayo.edu
- Phone: (507) 293-2565
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.