Evaluating inflammation and endothelial dysfunction in patients with myocardial infarction and non-obstructive coronary arteries
Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
This study is trying to see if certain markers of inflammation and blood vessel health can help understand heart attacks in people with blocked arteries compared to those with clear arteries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospital Universitario Getafe Academic / other |
| Locations | 1 site (Getafe, Madrid) |
| Trial ID | NCT06446895 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the role of inflammation and endothelial dysfunction biomarkers in patients experiencing myocardial infarction with non-obstructive coronary arteries (MINOCA). It will compare these biomarkers in MINOCA patients to those with myocardial infarction and obstructive coronary arteries (MICAD). Blood samples will be collected at three different time points: within 24 hours of symptom onset, at discharge, and two months post-MI, to assess the association of these biomarkers with the risk of MINOCA using logistic regression analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are patients admitted with myocardial infarction who undergo coronariography and are willing to provide informed consent.
Not a fit: Patients who do not sign informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of MINOCA and lead to improved diagnostic and therapeutic strategies for affected patients.
How similar studies have performed: While there have been studies on myocardial infarction, this specific focus on MINOCA and its biomarkers is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients admitted with Myocardial Infarction and undergo a coronariography * Patients must sign informed consent. Exclusion Criteria: * Patients who don´t sign informed consent
Where this trial is running
Getafe, Madrid
- Hospital Universitario de Getafe — Getafe, Madrid, Spain (Recruiting)
Study contacts
- Study coordinator: Maria Jesus Espinosa, Md
- Email: mariajesusespinosapascual@gmail.com
- Phone: 636581691
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.