Evaluating infections in lung transplant recipients
Prospective Evaluations of Infectious Complications in Lung Transplant Recipients
This study is trying to see how common certain infections are in people who have had a lung transplant and if these infections can lead to complications like bronchiolitis obliterans.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Trial ID | NCT00177918 on ClinicalTrials.gov |
What this trial studies
This observational study aims to prospectively assess the prevalence and outcomes of viral and Chlamydia pneumoniae infections in lung transplant recipients. Patients will be monitored by pulmonologists, and their blood and bronchoalveolar lavage (BAL) samples will be collected for analysis. The study will investigate the correlation between C. pneumoniae infection and the development of bronchiolitis obliterans, a common complication after lung transplantation. Additionally, the research will explore the potential to predict infections and rejection through tissue samples obtained during standard bronchoscopy procedures.
Who should consider this trial
Good fit: Ideal candidates include individuals who have undergone or are scheduled to undergo lung transplantation at the University of Pittsburgh Medical Center.
Not a fit: Patients who are not willing to participate in the research study will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management of infections and rejection in lung transplant patients, enhancing their overall outcomes.
How similar studies have performed: Other studies have shown success in understanding infections in transplant populations, but this specific approach to correlating C. pneumoniae with bronchiolitis obliterans is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have undergone lung transplantation or will undergo a lung transplant at the University of Pittsburgh Medical Center and are alive following transplant period will be eligible for the study. Exclusion Criteria: * Subjects not willing to participate in the research study.
Where this trial is running
Pittsburgh, Pennsylvania
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: EJ Kwak, MD — University of Pittsburgh Medical Center
- Study coordinator: EJ Kwak, MD
- Email: kwakej@upmc.edu
- Phone: 412-648-6401
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.