Evaluating infant crying as a predictor of neurodevelopment
Official title: Infant Crying, a Bioacoustic Prognostic Signal for Neurodevelopment
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT06332521 · Data updated 2026-11-12
This study is trying to see if the sounds of crying from newborns can help predict how well they will develop by the time they are two years old.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 4 Days |
| Sex | All |
| Enrollment | 1100 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Status | Recruiting |
| Started | March 20, 2024 |
| Main results expected | March 1, 2028 |
| Study ends | March 1, 2028 |
| Registry record updated | May 28, 2025 |
| Trial ID | NCT06332521 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include full-term infants over 37 weeks and premature infants under 37 weeks born at the Saint-Etienne University Hospital.
✕Probably not a fit
Patients who may not benefit include those with antenatal pathology, perinatal asphyxia, or abnormal audiological screening results.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to analyze the acoustic characteristics of crying in both term and premature infants at birth. By documenting a large database of crying recordings, the study seeks to correlate these bioacoustic features with neurodevelopmental outcomes assessed at two years of age. Utilizing deep learning and artificial intelligence, the researchers will process the data to explore the relationship between crying acoustics and clinical data from full-term infants who undergo systematic neurodevelopmental monitoring. The ultimate goal is to determine if the characteristics of an infant's cry can serve as a prognostic signal for their neurofunctional integrity.
Why it matters
Potential benefit: If successful, this study could provide early indicators of neurodevelopmental issues in infants, allowing for timely interventions.
How similar studies have gone: While the approach of using bioacoustic signals for neurodevelopmental prediction is innovative, similar studies have not been widely reported, indicating this may be a novel exploration.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * For a full-term baby \> 37 weeks * For a premature baby \< 37 weeks * Born in the maternity ward of the Saint-Etienne University Hospital * Holder of parental authority having received informed information about the study and their right to object * Holder of parental authority affiliated to or beneficiary of a social security system * Eutrophic between the 10th and 90th percentile on the neonatal curves) Exclusion Criteria: * Refusal of participation by the holder of parental authority * Antenatal pathology, nor perinatal asphyxia * Holder of minor parental authority * Holder of parental authority under curatorship or guardianship * Abnormal T1 audiological screening test.
Where it's running
-
Chu de Saint-Etienne
Saint-Etienne, France Recruiting
Study contacts
- Principal investigator: HUGUES PATURAL, MD-PhD — Chu de Saint-Etienne
- Study coordinator: HUGUES PATURAL, MD-PhD
- Email: hugues.patural@chu-st-etienne.fr
- Phone: (0)4 77 82 85 42
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.