Evaluating immune responses to the flu vaccine in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the immune response generated by the killed influenza vaccine in healthy volunteers. Participants will receive a licensed seasonal inactivated flu vaccine and provide blood and bone marrow samples for analysis. The study will monitor humoral immunity at multiple time points: 7 days, 28 days, 90 days, and one year post-vaccination. Researchers will evaluate the magnitude, clonal diversity, and persistence of B-cell responses to the vaccine over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All genders, races and ethnic groups (inclusive of women and minorities) are eligible for this trial, as influenza and the associated range of clinical issues accompanying influenza infection can impact people of all genders, races and ethnic groups. It is anticipated that the distribution of study participants will be diverse with regard to these demographics.
* Adults able to provide consent on their own
* Healthy adults

Exclusion Criteria:

* Adults unable to consent
* Women who are pregnant or nursing a child may not take part in this study. If a woman of childbearing potential is enrolled in this study, she and the study doctor must agree on a method of birth control to use throughout the study. Enrollees who think that they may have gotten pregnant during the study must tell the study doctor immediately. Pregnant women will be taken out of the study.
* Prisoners
* Cognitively impaired or individuals with impaired decision-making capacity
* Individuals who are vulnerable to coercion or undue influence (human fetuses, or neonates of uncertain viability or non-viable neonates, minors/children, and cognitively impaired adults) will not be eligible for participation in this study.

Where it's running

• Emory University Hospital
  Atlanta, Georgia, United States Recruiting

Study contacts

• Principal investigator: Edmund K Waller, MD, PhD — Emory University
• Study coordinator: Jennifer C Truell, MA, MPH
• Email: jennifer.carter.truell@emory.edu
• Phone: 404-778-0014

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.