Evaluating human tissue models for cancer treatment
Systematic Evaluation of Human Explant Model Systems Engineering
This study is testing a new way to use human tissue samples to see how different cancer treatments work, aiming to make therapy more personalized for people with solid tumors.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Heidelberg Academic / other |
| Locations | 1 site (Heidelberg) |
| Trial ID | NCT04671654 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on improving personalized therapy for solid tumors by utilizing a human tumor explant model system. It aims to enhance the understanding of tissue responses to various therapies, including immunotherapy, chemotherapy, and radiation. By analyzing human donor tissue in a specialized bioreactor, the study seeks to predict therapy outcomes and resistance mechanisms more effectively than traditional animal models or cell cultures. The ultimate goal is to refine therapy management in oncology based on dynamic tissue changes during treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients with accessible tissue material for explant model generation.
Not a fit: Patients with curatively resected or treated tumors may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized cancer treatments for patients.
How similar studies have performed: While the approach of using human explant models is innovative, similar studies have shown promise in enhancing understanding of cancer therapies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Tissue material for Explant Model generation available or accessible Exclusion Criteria: * curatively resected/treated tumors
Where this trial is running
Heidelberg
- University of Heidelberg / NCT — Heidelberg, Germany (Recruiting)
Study contacts
- Study coordinator: Azaz Ahmed, Dr. med.
- Email: Azaz.Ahmed@med.uni-heidelberg.de
- Phone: +49-6221-56-7229
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.