Evaluating human neuron activity using brain tissue slices.
Official title: Inside a Neuron - Ex Vivo Evaluation of Cerebral and Cerebellar Neuronal Activity Through Electrophysiological and Imaging Techniques on Human Tissue from Surgical Activity.
Run by Fondazione IRCCS Policlinico San Matteo di Pavia · NCT06896331 · Data updated 2026-11-12
This study is testing how human brain cells work by using slices of brain tissue from surgery to see how they respond to different signals and if their behavior changes in disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Pavia) |
| Status | Recruiting |
| Started | September 17, 2024 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | March 26, 2025 |
| Trial ID | NCT06896331 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with a primary or secondary brain or cerebellum tumor who are scheduled for partial resection.
✕Probably not a fit
Patients who are only undergoing a biopsy for their brain or cerebellum tumor may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to understand the functioning of human neurons by utilizing brain tissue slices obtained during neurosurgical procedures. By employing advanced techniques such as patch-clamp and high-density microelectrode arrays (HD-MEA), researchers will analyze how these neurons respond to various inputs and how their functioning may differ in pathological conditions. This approach allows for a more accurate representation of human neuronal activity compared to traditional animal models, potentially leading to new therapeutic insights.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of human neural function and inform future treatments for neurological disorders.
How similar studies have gone: While studies using animal models have shown success with similar techniques, this approach using human tissue is relatively novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with a brain/cerebellum primary or secondary tumor for whom at least partial resection has been planned. Exclusion Criteria: * patients with a brain/cerebellum primary or secondary tumor for whom a biopsy has been planned
Where it's running
-
Fondazione IRCCS Policlinico San Matteo di Pavia
Pavia, Pavia, Italy Recruiting
Study contacts
- Study coordinator: Francesco Guerrini, MD
- Email: f.guerrini@smatteo.pv.it
- Phone: +39 0382502780
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.