Evaluating human neuron activity using brain tissue slices.
Inside a Neuron - Ex Vivo Evaluation of Cerebral and Cerebellar Neuronal Activity Through Electrophysiological and Imaging Techniques on Human Tissue from Surgical Activity.
Fondazione IRCCS Policlinico San Matteo di Pavia · NCT06896331
This study is testing how human brain cells work by using slices of brain tissue from surgery to see how they respond to different signals and if their behavior changes in disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia (other) |
| Locations | 1 site (Pavia, Pavia) |
| Trial ID | NCT06896331 on ClinicalTrials.gov |
What this trial studies
This observational study aims to understand the functioning of human neurons by utilizing brain tissue slices obtained during neurosurgical procedures. By employing advanced techniques such as patch-clamp and high-density microelectrode arrays (HD-MEA), researchers will analyze how these neurons respond to various inputs and how their functioning may differ in pathological conditions. This approach allows for a more accurate representation of human neuronal activity compared to traditional animal models, potentially leading to new therapeutic insights.
Who should consider this trial
Good fit: Ideal candidates are patients with a primary or secondary brain or cerebellum tumor who are scheduled for partial resection.
Not a fit: Patients who are only undergoing a biopsy for their brain or cerebellum tumor may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of human neural function and inform future treatments for neurological disorders.
How similar studies have performed: While studies using animal models have shown success with similar techniques, this approach using human tissue is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients with a brain/cerebellum primary or secondary tumor for whom at least partial resection has been planned. Exclusion Criteria: * patients with a brain/cerebellum primary or secondary tumor for whom a biopsy has been planned
Where this trial is running
Pavia, Pavia
- Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Pavia, Italy (RECRUITING)
Study contacts
- Study coordinator: Francesco Guerrini, MD
- Email: f.guerrini@smatteo.pv.it
- Phone: +39 0382502780
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Human Neural Cells Functioning, INSANE, neurons, human, glioma, brain, patch-clamp, HD-MEA