Evaluating high ammonia levels in patients treated with Erwinia asparaginase

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the incidence of symptomatic hyperammonemia in patients undergoing treatment with recombinant Erwinia asparaginase for hematopoietic and lymphatic system neoplasms, particularly acute lymphoblastic leukemia. The primary objectives include determining how many patients develop high ammonia levels and identifying those at risk for this condition. Participants will provide blood samples, complete surveys, and have their medical records reviewed to gather comprehensive data on the effects of the treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Followed by pediatric hematology/oncology
* Receiving recombinant Erwinia asparaginase for treatment of malignancy

Exclusion Criteria:

* Patients \< 1 year of age
* Patients who have previously received recombinant Erwinia asparaginase within the past two weeks

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Catherine E. Martin, PharmD, RPh — Mayo Clinic in Rochester
• Study coordinator: Clinical Trials Referral Office
• Email: mayocliniccancerstudies@mayo.edu
• Phone: 855-776-0015

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.