Evaluating heart recovery after surgery for aortic regurgitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of surgical correction for chronic aortic regurgitation on the reverse remodeling of the left ventricle in patients with functional mitral regurgitation. It aims to monitor changes in left ventricle volume and function post-surgery using echocardiography, while also assessing the quality of life in participants. The study focuses on patients with severe enlargement of the left heart chambers and evaluates how surgical intervention influences recovery outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18 years
* Planned primary elective surgery for chronic aortic regurgitation
* Presence of functional mitral regurgitation
* End-diastolic volume of the left ventricle \>= 250 ml

Exclusion Criteria:

* Infectious endocarditis
* History of myocardial infarction
* Indications on simultaneous myocardial revascularisation
* Acute aortic regurgitation of any etiology
* Previously diagnosed dilatation of the left ventricle, not associated with the development of aortic regurgitation
* Long-term persistent or permanent form of atrial fibrillation
* Pregnancy in the first 12 months after surgery
* Simultaneous participation in other studies
* Presence of implanted pacemakers
* Refusal to sign informed consent
* Acute coronary event diagnosed within 12 months after aortic valve surgery
* Indications for resynchronization therapy or permanent right ventricular pacing in the first 12 months after aortic valve surgery
* Re-do cardiac surgery for any reason within 12 months after aortic valve surgery

Where it's running

• Petrovsky National Research Center of Surgery
  Moscow, Russia Recruiting
• Voronezh Regional Clinical Hospital No. 1
  Voronezh, Russia Recruiting

Study contacts

• Study coordinator: Eduard Charchyan, professor
• Email: charchmed@yahoo.com
• Phone: +79262174114

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.