Evaluating heart imaging techniques for coronary disease treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the safety and effectiveness of computed tomography perfusion (CTP) guided revascularization compared to fractional flow reserve (FFR) guided revascularization in patients with coronary artery disease. Participants will be evaluated based on their symptoms and the severity of their coronary artery blockages. The study will include patients aged 20 and older who meet specific criteria related to their heart condition and will exclude those with certain severe health issues. The goal is to determine which imaging technique provides better outcomes for patients undergoing treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 20 and more
* Diagnosed angina or angina equivalent symptom or positive exercise treadmill test
* Patients with intermediate- or high-risk probability of CAD defined by Diamond and Forester
* 70 % stenosis or more in coronary CTA
* Willing to provide informed, written consent

Exclusion Criteria:

* Requirement for surgical procedure
* Cardiogenic shock and/or need for mechanical/pharmacologic hemodynamic support
* Recent STEMI (\<5 days)
* Non STEMI, if the cardiac troponin is not stable or starting to decline
* Left ventricular ejection fraction \<30%
* Life expectancy \<2 years
* Impaired renal function with an effective glomerular filtration rate less than 30mL/min/1.73 ㎡ or creatinine more than 2.0 mg/dL
* Undergoing evaluation for organ transplantation
* Participation or planned participation in another cardiovascular clinical trial
* Pregnancy
* Inability to take dual antiplatelet therapy for six months
* Previous CABG
* Left main disease requiring revascularization
* Any target lesion with in-stent restenosis
* NYHA class 3 or 4a
* Severe and persistent angina with severe limitation in everyday living activities (Canadian Cardiovascular Society grading Class IV)

Where it's running

• Asan Medical Center
  Seoul, Songpa-Gu, South Korea Recruiting
• Hallym University Sacred Heart Hospital
  Anyang, South Korea Completed
• Gangwon National Univ. Hospital
  Chuncheon, South Korea Completed
• Keimyung University Dongsan Medical Center
  Daegu, South Korea Completed
• Pusan National University Hospital
  Pusan, South Korea Enrolling by invitation
• Pusan National University Yangsan Hospital
  Pusan, South Korea Completed

Study contacts

• Principal investigator: Byoung-Wook Choi, MD — Severance Hospital
• Study coordinator: Young-Hak Kim, MD
• Email: mdyhkim@amc.seoul.kr

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.