Evaluating heart function during exercise after ablation for atrial fibrillation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to assess changes in left atrial reservoir function and overall exercise capacity in patients who have undergone catheter ablation for paroxysmal atrial fibrillation. Participants will undergo various evaluations, including self-reported questionnaires and cardiopulmonary exercise tests, to measure their heart performance during physical activity. The study will track these changes over time to better understand the impact of the ablation procedure on exercise capacity and heart function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Diagnosis of paroxysmal AF
* Left ventricular ejection fraction ≥50%
* Scheduled for catheter ablation
* Able to speak, hear, and read English
* Willing and able to provide informed consent

Exclusion Criteria:

* Persistent or permanent AF
* Prior ablation (catheter based or surgical) for AF
* Significant sinus node dysfunction
* Implanted pacemaker or defibrillator
* Contraindication to or inability to complete cardiovascular magnetic resonance study
* Contraindication to or inability to complete exercise testing
* Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
* Severe left ventricular hypertrophy
* Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:

  * Hypertrophic cardiomyopathy
  * Cardiac amyloidosis
  * Constrictive pericarditis
* Pulmonary arterial hypertension
* Prior cardiac surgery
* Active pregnancy

Where it's running

• Virginia Commonwealth University
  Richmond, Virginia, United States Recruiting

Study contacts

• Principal investigator: Cory Trankle — Virginia Commonwealth University
• Study coordinator: Pamela Grizzard
• Email: pamela.grizzard@vcuhealth.org
• Phone: 804-628-6234

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.