Evaluating hearing and balance in children and young adults with Osteogenesis Imperfecta

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the presence of vestibular deficits in children and young adults aged 12 to 20 years with Osteogenesis Imperfecta (OI). Participants will undergo audiometric, immittance, and vestibular assessments, followed by CT or MRI scans if specific hearing loss types or vestibular deficits are identified. The study seeks to establish correlations between genetic types, severity of OI, and audiovestibular phenotypes, contributing to a better understanding of the condition's impact on hearing and balance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients between the ages of 12-20 years at the time of inclusion
* Diagnosis of Osteogenesis Imperfecta of any type
* Currently followed by a physician at the CRMR OI
* Information and non-opposition of major patients, holders of parental authority and minor patients to participate in the study

Exclusion Criteria:

* Patients with hearing loss of alternate origin e.g. Cochlear nerve deficiency, atresia, etc.
* Neurological or developmental deficits limiting participation
* Cervico-occipital instability e.g. Chiari's malformation
* Limitations in mobility of the spine e.g. scoliosis, spinal fractural fusion
* Ophthalmologic pathologies e.g. strabism or severe refraction disorder
* Patients under AME (State Medical Aid)
* Protected adult patients, adults unable to express their consent, pregnant or breastfeeding women

Where it's running

• Hôpital Necker-Enfants Malades
  Paris, France Recruiting

Study contacts

• Principal investigator: Natalie Loundon, MD, PhD — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Natalie Loundon, MD, PhD
• Email: natalie.loundon@aphp.fr
• Phone: 1 71 39 67 82

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Registry for Osteogenesis Imperfecta

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.